74693-62-2

Usage

Uses

Used in Pharmaceutical Industry:
1-Ethyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carbohydrazide is used as a potential antibacterial agent for its pharmacological properties. It is being studied for its ability to combat bacterial infections, with its precise mode of action and biological activities under investigation.
Used in Organic Synthesis:
In the field of organic synthesis, 1-Ethyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carbohydrazide serves as a valuable intermediate. Its unique chemical structure allows it to be a building block for the development of other compounds with potential pharmaceutical applications, contributing to the creation of new drugs and therapeutic agents.

InChI:InChI=1/C12H13N3O3/c1-2-15-8-6-4-3-5-7(8)10(16)9(12(15)18)11(17)14-13/h3-6,18H,2,13H2,1H3,(H,14,17)

Upstream product

• 52851-60-2 ethyl 1-ethyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylate 

Downstream Products

• 331963-48-5 C₁₉H₁₆ClN₃O₄ 
• 331963-45-2 C₁₉H₁₆ClN₃O₄ 
• 331963-51-0 C₁₉H₁₆BrN₃O₄ 
• 331963-61-2 C₁₉H₁₆N₄O₆ 
• 331963-56-5 C₂₀H₁₉N₃O₄ 
• 300836-36-6 C₁₉H₁₅N₅O₈ 
• 331963-74-7 C₁₉H₁₉N₃O₅S 
• 74693-63-3 1-Ethyl-4-hydroxy-2-oxo-1,2-dihydro-quinoline-3-carboxylic acid [1-(5-nitro-furan-2-yl)-meth-(E)-ylidene]-hydrazide 

Relevant academic research and scientific papers

4-hydroxy-2-quinolones 165*. 1-R-4-hydroxy-2-oxo-1,2-dihydro- quinoline-3-carbaldehydes and their thiosemicarbazones. Synthesis, structure, and biological properties

Two variants are discussed of the synthesis of 1-R-4-hydroxy-2-oxo-1,2- dihydroquinoline-3-carboxylic acid β-N-tosylhydrazides which undergo a McFayden-Stevens reaction to give 1-R-4-hydroxy-2-oxo-1,2-dihydroquinoline-3- carbaldehydes in high yields. It was shown that the thiosemicarbazones prepared from them exist in the solid state exclusively in the syn-form while in solution a hydrazone ? enhydrazine tautomerism is observed. The results of a study of the antitubercular activity of the synthesized compounds are reported.

4-HYDROXYQUINOLONES-2. 5. SYNTHESIS AND PHYSICOCHEMICAL AND BIOLOGICAL PROPERTIES OF NEW PYRAZOLE DERIVATIVES

Hydrazinolysis of 1-R-3-carbethoxy-4-hydroxyquinolones-2 was used to synthesize the corresponding hydrazides; thermal cyclodehydration of the latter yielded 3-oxopyrazolo--5-R-quinolones-4.Findings relating to their analgesic and antiphlogistic activity are outlined.