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• 74652-45-2 endo,endo-N-(p-nitrophenyl)-1,8,9,10,11,11-hexachloro-3,6-epoxytricyclo<6.2.1.0^2,7>undec-9-ene-4,5-dicarboximide 

Relevant academic research and scientific papers

Synthesis of Pyrazole-linked Norcantharidin Analogues of Substituted Chromones

Eighteen novel pyrazole-linked norcantharidin derivatives substituted by chromone ring were synthesized in a single step by the [3+2] 1,3-dipolar cycloaddition reaction of norcantharidin derivatives of substituted aromatic amines with hydrazone in the presence of chloramine-T as compared to the conventional method.

Structural and theoretical study of four novel norcantharidine derivatives: Two new cases of conditional isomorphism

Structural and theoretical studies of four novel 5,6-dehydronorcantharidine (DNCA)/norcantharidine (NCA) derivatives, namely (3aR,4S,7R,7aS)-2-phenyl-3a,4,7,7a-tetrahydro-4,7-epoxy-1H-isoindole-1,3(2H)-dione, C14H11NO3 (DNCA-A), (3aR,4S,7R,7aS)-2-(4-nitrophenyl)-3a,4,7,7a-tetrahydro-4,7-epoxy-1H-isoindole-1,3(2H)-dione, C14H10N2O5 (DNCA-NA), (3aR,4S,7R,7aS)-2-(4-nitrophenyl)-3a,4,5,6,7,7a-hexahydro-1H-4,7-epoxyisoindole-1,3(2H)-dione, C14H12N2O5 (NCA-NA), and (3aR,4S,7R,7aS)-2-(2-hydroxyethyl)-3a,4,5,6,7,7a-hexahydro-1H-4,7-epoxyisoindole-1,3(2H)-dione, C10H13NO4 (NCA-AE), are reported. The supramolecular interactions and single-crystal structural characteristics of these molecules, together with the crystal structures of four other similar molecules, i.e. NCA-A (the 4-phenyl derivative of NCA-NA), DNCA-AE (the 5,6-unsaturated derivative of NCA-AE), DNCA and NCA, were analysed. Surprisingly, DNCA-A and NCA-A, as well as DNCA-NA and NCA-NA, proved to be isomorphic, while DNCA-AE and NCA-AE, as well as DNCA and NCA, have very different crystal structures. These are very rare isostructural examples between unsaturated and saturated oxanorbornene/oxanorbornane derivatives. To further explore how noncovalent interactions (NCIs) affect the degree of isomorphism in this particular series of rigid molecules where there is a fairly limited conformational degree of freedom, all four pairs of crystal structures were analyzed in parallel. The differentiation in NCIs which entails the packing mode of similar molecules is supported by energy calculations based on real or exchanged crystal structures. Our results show that minor structural differences may result in very different supramolecular interactions, and so lead to altered packing modes in the crystalline solids. Even if isostructurality sometimes occurs, the possibility of various molecular packing types cannot be ruled out. On the other hand, isomorphism may just be the result of kinetic possibilities instead of relative thermodynamic stabilities. Though crystal structure prediction is formidable, the comparison method based on existing crystal structures and quantum calculations can be used to predict the probability of isomorphism. This understanding will help us to design new norbornene derivatives with specified structures.

Synthesis of Isoxazole-Linked Norcantharidin Analogues of Substituted Chromones

Eighteen novel norcantharidin derivatives, which were substituted by chromone ring, were synthesized in a single step by the [3 + 2] 1,3-dipolar cycloaddition reaction with three oximes in the presence of chloramine-T when compared with the conventional method.

Containing chromon structure-isoxazole Norcantharidin derivative and its preparation method and application

The invention discloses novel chromone structure containing isoxazole norcantharidin derivatives as well as a preparation method and an application thereof. The preparation method is characterized by introducing isoxazole rings to C5 and C6 in a norcantharidin structure by using a 1,3-dipolar cycloaddition method to react with chromone derivatives to import the chromone structures, thus synthesizing a series of totally six novel chromone structure containing isoxazole norcantharidin derivatives. The isoxazole norcantharidin derivatives are applied to synthesis of antitumor drugs and have broad application prospects.

1,3-Dipolar cycloaddition reaction: Synthesis of novel 5,6- dehydronorcantharidin derivatives of substituted aromatic amines with potential antitumor activities

Twelve novel compounds were synthesized by the [3+2] 1,3-dipolar cycloaddition reaction of 5,6-dehydronorcantharidin derivatives of substituted aromatic amines with nitrile oxides. The structure and the configuration of all compounds were confirmed by 1H NMR, IR, MS, 1H- 1HCOSY, and NOESY spectral data. Their anti-tumor activities are under way.