7473-85-0Relevant academic research and scientific papers
Synthesis of N-containing heterocycles via mechanochemical grinding and conventional techniques
Fahmy, Amin F.M.,El-Sayed, Amira A.,Hemdan, Magdy M.,Hassaballah, Aya I.,Mabied, Ahmed F.
, p. 2679 - 2686 (2017/11/10)
Mechano heterocyclic chemistry is a recent quickly growing technique draws the attention of hetrocyclic chemists towards the use of grindstone technique in a solvent free green efficient clean synthesis of many heterocyclic systems. α,β-Epoxy ketones were used as a unique scaffold for synthesis of stable hydroxyazoles. The key advantage of grinding technique over the conventional thermal technique includes its simple, solvent free conditions, as well as facile work up with high yield economy. It is also successful in achieving three of the green chemistry objectives of a solvent free, high atom economy, save energy thus combining the features of both economic and environmental advantages.
Manganese-Promoted Oxidative Cyclization of Unsaturated Oximes Using Molecular Oxygen in Air under Ambient Conditions
Yamamoto, Daisuke,Oguro, Takuto,Tashiro, Yuuki,Soga, Masayuki,Miyashita, Kazuhito,Aso, Yoshiaki,Makino, Kazuishi
supporting information, p. 5216 - 5219 (2016/11/13)
A highly efficient manganese-promoted oxidative cyclization of unsaturated oximes to afford the corresponding 4,5-dihydroisoxazoline alcohols was developed. A very low loading (generally 0.1–0.2 mol-%) of Mn(acac)3(acac = acetylacetonate) promoted the oxidative cyclization through the direct incorporation of molecular oxygen present in air (open flask) at room temperature.
Nitrosation of Methyl and Phenyl Styryl Ketoximes Under Oxygen. Formation of 4-Nitro-1-hydroxypyrazole 2-Oxides and 3,5-Diphenyl-4-nitrato-4,5-dihydroisoxazole
Hansen, John F.,Georgiou, Paul J.
, p. 1487 - 1492 (2007/10/02)
The nitrosation of the oximes of 4-phenyl-3-buten-2-one and 1,3-diphenyl-2-propen-1-one under oxygen has been reinvestigated.In addition to 4-oxo- and 4-oximino-4H-pyrazole 1,2-dioxides previously reported, the reactions give 4-nitro-1-hydroxypyrazole 2-oxides.In the case of 1,3-diphenyl-2-propen-1-one oxime the nitrosation reaction also gives 3,5-diphenyl-4-nitrato-4,5-dihydroisoxazole.Evidence is presented suggesting that the nitrate ester is formed through the rearrangement of a peroxynitrite intermediate.
A facile method for the preparation of 4-hydroxy-Δ2-isoxazolines via a cycloaddition/oxidation procedure employing nitrile oxides and vinylboronic esters
Wallace, Richard H.,Liu, Jinchu
, p. 7493 - 7496 (2007/10/02)
The 1,3-dipolar cycloaddition of aromatic nitrile oxides with trans-1,2-disubstituted vinylboronic esters affords the 4-boronic ester substituted Δ2-isoxazoline as the major regioisomer. If the reaction mixture is treated with t-BuOOH the corre
A Simple Synthetic Method of trans-5-Aryl and 5-Cyclopropyl Derivatives of 2-Isoxazolin-4-ol via Intramolecular Ring Opening of α,β-Epoxy Ketone Oximes
Ito, Shoei,Sato, Masahiro
, p. 2739 - 2741 (2007/10/02)
trans-5-Aryl and 5-cyclopropyl derivatives of 2-isoxazolin-4-ol were conveniently prepared from trans-2-aryl- and 2-cyclopropyl-3-benzoyloxiranes and hydroxylamine hydrochloride in the presence of pyridine via an intramolecular opening of oxirane by the oxygen nucleophile of the oximino group.
Methylthiomethyl Nitrones from the E- and Z-Oximes of E-Chalcone and Phenyl Vinyl Ketone: -Dipolar Cyclisations
Ooi, Ngan Sim,Wilson, David A.
, p. 4726 - 4736 (2007/10/02)
The E-oximes of E-chalcone (1,3-diphenylpropenone; benzalacetophenone) and phenyl vinyl ketone (1-phenylpropenone) were isomerised by alkali in dimethyl sulphoxide to equilibrium mixtures of E- and Z-isomers, from which the pure Z-isomers have been obtain
