7474-11-5

Usage

Uses

Used in Environmental Monitoring:
DNPH is utilized as a detection agent for carbonyl compounds, particularly useful in the identification and measurement of aldehydes and ketones. Its ability to form brightly colored derivatives upon reaction with these functional groups makes it a valuable tool in environmental monitoring, where the detection of specific pollutants is crucial.
Used in Industrial Process Control:
In the industrial sector, DNPH serves as a reagent for the analysis of carbonyl compounds, which are often intermediates or byproducts in various chemical processes. Its selective detection capabilities aid in process optimization and quality control by ensuring the accurate measurement of key compounds.
Used in Research Laboratory Analysis:
DNPH is also widely used in research laboratories for the detection and quantification of carbonyl compounds. Its versatility and stability make it an essential tool for scientific investigations involving aldehydes and ketones, contributing to the advancement of chemical research and understanding.

Upstream product

• 119-26-6 (2,4-dinitro-phenyl)-hydrazine 
• 123-54-6 acetylacetone 
• 67-51-6 3,5-dimethyl-1H-pyrazole 
• 2486-07-9 2,4-dinitrophenyl phenyl ether 
• 105002-68-4 1-(3,5-dinitrophenyl)hydrazine 
• 97-00-7 1-chloro-2,4-dinitro-benzene 

Downstream Products

• 60418-59-9 C₁₁H₁₀N₄O₂ 
• 1215212-19-3 C₁₁H₉FN₄O₄ 
• 108444-23-1 1-(2,4-Dinitro-phenyl)-3,5-dimethyl-1H-pyrazole-4-carboxylic acid 
• 67-51-6 3,5-dimethyl-1H-pyrazole 
• 1670-17-3 N,N-dimethyl-2,4-dinitroaniline 
• 97-02-9 2,4-Dinitroanilin 
• 2044-88-4 N-methyl-2,4-dinitroaniline 

Relevant academic research and scientific papers

1-(2,4-dinitrophenyl)-3,5-dimethylpyrazole

The asymmetric unit of the title compound consists of two independent molecules of C11H10N4O4. The pyrazole and dinitrophenyl rings are individually planar and are twisted about the N - Csp2bond joini

Preparation method of pyrazole derivative

The present invention discloses a method for preparing a pyrazole derivative. The method comprises the following steps: the arylhydrazine derivative is mixed with an alkyldione derivative, reaction, to obtain a pyrazole derivative; wherein the structure of the arylhydrazine derivative is as follows: the structure of the alkyldione derivative is as follows: the structure of the pyrazole derivative provided by the present invention is green safe, simple and efficient, mild conditions, no catalyst, low cost, high synthesis efficiency. This method can synthesize a variety of 1,3,4,5-tetra-substituted pyrazole derivatives, and the method can be widely used in the field of organic synthesis.

HBF4/ACN: A simple and efficient protocol for the synthesis of pyrazoles under ambient reaction conditions

An efficient and novel protocol for pyrazole synthesis has been developed by using fluoroboric acid as the acid catalyst. Simple and easily available 1,3-diketone and hydrazine derivatives are taken as the substrates for this purpose. The reaction entails

Nano-SnCl4 /SiO2 as a catalyst for one-pot synthesis of substituted 1h-pyrazoles as antifungal and cytotoxic agents

A simple and efficient method was developed for the synthesis of pyrazole derivatives via a one-pot reaction of 1,3-diketone and substituted hydrazines in the presence of nano-SnCl4/SiO2 as a mild catalyst. A series of some pyrazole derivatives (P1-P11) was synthesized and evaluated as anti-fungal and anti-cancer agents. Compounds P10 and P11 were demonstrated. The antimicrobial activities of the synthetic compounds showed that compounds P10 and P11 most excellently inhibited the growth of dermatophytes or Aspergillus species, respectively. Therefore, the cytotoxic activities of the-se compounds on two human cancer cell lines, A549 (lung cancer) and MCF-7 (breast cancer) were further assessed. Hence, results demonstrated that beside antifungal activity, P10 had also desirable cy-totoxic effect on investigated cancerous cell lines, even higher than cisplatin.

Transition metal containing ionic liquid-assisted one-pot synthesis of pyrazoles at room temperature

Abstract: The feasible and one of the green ways to synthesize organic compounds especially pyrazole and its derivatives are systematically presented. The one-pot synthesis of pyrazole was achieved by condensation of various hydrazines and 1,3-diketone derivatives at room temperature using transition metal-based ionic liquids. Herein, the unique combination of Fe(III) with ionic liquid is explored and utilized as an efficient homogeneous catalyst for the synthesis of pyrazole and its derivatives. The homogenous catalyst thus synthesised was re-used up to the fourth cycle (with 90%, 88%, 84%, 78% yields respectively). Graphic abstract: Pyrazoles are synthesized in the presence of transition metal-based ionic liquids at room temperature. From the green chemistry perspective, ionic liquids are considered as green solvents which have gained remarkable attention because of its non-toxic, non-corrosive and non-flammable nature while the presence of transition metal as a part of counter anion gives it more catalytic activity. [Figure not available: see fulltext.].

Cu1.5PMo12O40-catalyzed condensation cyclization for the synthesis of substituted pyrazoles

A convenient and direct approach has been developed for the preparation of pyrazole derivatives by the condensation cyclization of hydrazines/hydrazide and 1,3-diketones in the presence of Cu1.5PMo12O40 (0.33?mol%) under mild conditions (r.t.-60?°C, 10–30?min). Notably, the reaction was found to be scalable as 99% yield was obtained when the reaction was performed at a 5-mmol scale. This solvent-free and halogen-free catalytic system represents an effective economic and environmentally friendly method for the construction of pyrazoles.

Efficient Copper-Catalyzed Synthesis of Substituted Pyrazoles at Room Temperature

An efficient method for the synthesis of pyrazoles through a copper-catalyzed condensation reaction has been developed. The new catalytic system not only maintained a broad substrate scope but was also active under acid-free reaction conditions, overcoming the conventional requirement for an acid-catalyzed system. Furthermore, the copper catalyst enabled this reaction to be performed at room temperature and in a short reaction time.

Nano-TiO2: An efficient and reusable catalyst for the synthesis of 1,3,5-substituted pyrazoles

(Formula presented) A Nano-TiO2 is an efficient catalysis for the synthesis of 1,3,5-substituted pyrazoles via condensation of 1,3- diketones and hydrazines. Simple procedure, mild heating, solvent free, high yielding, and easy workup are some advantages of this protocol. The catalyst can be recovered easily and reused many times without significant loss in catalytic activity and selectivity.

A green protocol for catalyst-free syntheses of pyrazole in glycerol-water solution

An efficient green protocol for preparing pyrazole derivatives using glycerol and water as a mixture solvent is described. The advantages of the present method lie in using economic and environmentally benign solvent, no use of catalyst, mild reaction conditions and good yields.

A modified and practical synthetic route to indazoles and pyrazoles using tungstate sulfuric acid

Tungstate sulfuric acid-catalyzed Knorr reaction have been used as a simple, rapid, atom economic and green method for the synthesis of indazole and pyrazole derivatives based on the condensation of hydrazine derivatives and ss-dicarbonyl compounds under solvent-free conditions. It was found that the catalyst could be recovered and reused without significant loss of its activity. The use of this method provides a novel and improved modification of Knorr synthesis in terms of clean reaction profile, use of a safe catalyst and solvent-free conditions. A green method for the synthesis of indazole and pyrazole derivatives from the condensation of hydrazine derivatives with dicarbonyl compounds has been described. Tungstate sulfuric acid (TSA) catalyzed efficiently the reactions to give good yields.