74754-40-8

Upstream product

• 1009-61-6 1,4-Diacetylbenzene 

Downstream Products

• 134044-53-4 1-[4-(3-Nitroso-imidazo[1,2-a]pyrimidin-2-yl)-phenyl]-ethanone 
• 798568-38-4 2-Bromo-1-(4-imidazo[1,2-a]pyrimidin-2-yl-phenyl)-ethanone 
• 1029799-79-8 1-[4-(2-Amino-thiazol-4-yl)-phenyl]-ethanone 
• 134044-49-8 1-(4-Imidazo[1,2-a]pyrimidin-2-yl-phenyl)-ethanone 

Relevant academic research and scientific papers

N-(5-MEMBERED AROMATIC RING)-AMIDO ANTI-VIRAL COMPOUNDS

Disclosed are compounds having Formula (I) and the compositions and methods thereof for treating or preventing a viral infection mediated at least in part by a virus in the Flaviviridae family of viruses, wherein A, R2, m, R, V, W, T, Z, R

Photochemical Generation of Radical Anions of Photolabile Aryl Ketones

The radical anions of a series of substituted α-(aryloxy)acetophenones have been generated by trapping the solvated electron produced by 355-nm laser-induced photoionization of 4,4'-dimethoxystilbene in either acetonitrile or dimethylformamide (DMF).The radical anion of the parent ketone, α-phenoxyacetophenone, has λmax at 500 nm and decays with a rate constant 7 x 1E5 s-1.This rate constant reflects the rate of β-cleavage to generate phenoxide ion and phenylacyl radical.The rate constant for β-cleavage decreases for ketones with electron donating substituents in the α-aryloxy ring.Substituent effects on the acetophenone ring are in the opposite direction, and many of the 4-substituted (aryloxy)acetophenones have half-lives in excess of 10 μs that reflect a combination of second order processes and are not limited by β-cleavage.The generality of the photoionization/electron trapping method for the generation of radical anions of ketones with short-lived excited states that preclude direct excitation is illustrated by its application to other aryl ketones that undergo α-cleavage, β-phenyl quenching, and intramolecular hydrogen abstraction reactions.

Synthesis and antibacterial activity of some imidazo[1,2-a[pyrimidine derivatives

A series of 75 imidazo[1,2-a]pyrimidine derivatives were synthesized. The 'in vitro' antibacterial activity of these compounds and their corresponding α-bromoketones against a variety of gram (+), gram (-) bacteria and Mycobacterium species is reported. Some of the prepared derivatives exhibited potent antimicrobial activity.