74767-35-4

Upstream product

• 3437-95-4 2-Iodothiophene 
• 874-60-2 4-methyl-benzoyl chloride 

Downstream Products

• 74767-42-3 α-Carbamyl-β-(2-iodo-5-thienyl)-β-(p-tolyl)acrylonitrile 
• 74767-38-7 2-[1-(5-Iodo-thiophen-2-yl)-1-p-tolyl-meth-(E)-ylidene]-succinic acid 
• 74780-35-1 2-Iodo-4(H)-oxo-6-(p-tolyl)cyclopentathiophene-5-carboxamide 
• 74767-37-6 2-[1-(5-Iodo-thiophen-2-yl)-1-p-tolyl-meth-(E)-ylidene]-succinic acid 1-methyl ester 
• 74767-41-2 α-Cyano-β-(2-iodo-5-thienyl)-β-(p-tolyl)acrylonitrile 

Relevant academic research and scientific papers

Thiophene Ring Annelation: Part IV - Synthesis of 2-Iodo-7-(p-tolyl)-benzothiophene and 2-Iodo-4(H)-oxo-6-(p-tolyl)cyclopentathiophene-5-carboxamide

p-Tolyl 2-iodo-4-thienyl ketone (I) undergoes condensation with dimethyl succinate in the presence of potassium t-butoxide to give predominantly the trans(SC4H2I/CO2Me)-acid ester (IIa) which is converted into benzothiophene derivatives (IIIa and IIIb).Ketone (I) when allowed to react with malononitrile yields α-cyano-β-(2-iodo-4-thienyl)-β-(p-tolyl)acrylonitrile (IV) which undergoes cyclization in conc. sulphuric acid to give 2-iodo-4(H)-oxo-6-(p-tolyl)cyclopentathiophene-5-carboxamide (V) along with α-carbamyl-β-(2-iodo-4-thienyl)-β-(p-tolyl)acrylonitrile (VI).