74767-40-1Relevant academic research and scientific papers
Thiophene Ring Annelation: Part IV - Synthesis of 2-Iodo-7-(p-tolyl)-benzothiophene and 2-Iodo-4(H)-oxo-6-(p-tolyl)cyclopentathiophene-5-carboxamide
Moussa, H. H.,Haggag, B.
, p. 156 - 157 (2007/10/02)
p-Tolyl 2-iodo-4-thienyl ketone (I) undergoes condensation with dimethyl succinate in the presence of potassium t-butoxide to give predominantly the trans(SC4H2I/CO2Me)-acid ester (IIa) which is converted into benzothiophene derivatives (IIIa and IIIb).Ketone (I) when allowed to react with malononitrile yields α-cyano-β-(2-iodo-4-thienyl)-β-(p-tolyl)acrylonitrile (IV) which undergoes cyclization in conc. sulphuric acid to give 2-iodo-4(H)-oxo-6-(p-tolyl)cyclopentathiophene-5-carboxamide (V) along with α-carbamyl-β-(2-iodo-4-thienyl)-β-(p-tolyl)acrylonitrile (VI).
