7477-44-3Relevant academic research and scientific papers
Enantioselective solid-phase synthesis of α-amino acid derivatives
O'Donnell, Martin J.,Delgado, Francisca,Pottorf, Richard S.
, p. 6347 - 6362 (2007/10/03)
Wang-resin bound derivatives of glycine Schiff base esters are alkylated in the presence of quaternary ammonium salts derived from cinchonidine or cinchonine using phosphazene bases to give either enantiomer of the product α-amino acid derivatives in 51-89% ee.
Solid-phase synthesis of unnatural amino acids using unactivated alkyl halides
O'Donnell, Martin J.,Lugar, Charles W.,Pottorf, Richard S.,Zhou, Changyou,Scott, William L.,Cwi, Cynthia L.
, p. 7163 - 7166 (2007/10/03)
Conditions were developed for the efficient alkylation of the resin-bound benzophenone imine of glycine with a variety of unreactive alkyl halides. Alkylations were accomplished at room temperature in NMP using the phosphazene-type base, BEMP.
