74796-42-2Relevant academic research and scientific papers
Geiparvarin analogues. 2. Synthesis and cytostatic activity of 5-(4- arylbutadienyl)-3(2H)-furanones and of N-substituted 3-(4-oxo-2-furanyl)-2- buten-2-yl carbamates
Simoni,Manfredini,Tabrizi,Bazzanini,Baraldi,Balzarini,De Clercq
, p. 3172 - 3176 (2007/10/02)
In an attempt to determine some of the structural features of geiparvarin (1) that account for its cytostatic activity in vitro, a series of geiparvarin analogues (10a-i, l, 12, and 14-16) which contain novel modifications in the region of the olefinic do
An Entry to 5-(1-Alkenyl)-3(2H)-furanones through Cycloaddition of Phosphorus-Functionalized Nitrile Oxide to Acetylene Alcohols. An Effective Synthesis of Geiparvarin
Tsuge, Otohiko,Kanemasa, Shuji,Suga, Hiroyuki
, p. 323 - 326 (2007/10/02)
Cycloaddition of α-(diethoxyphosphoryl)acetonitrile oxide to acetylene alcohols is followed by an alkylation, a reductive cleavage of the N-O bond, and an acid-catalyzed cyclization to form 5-(diethoxyphosphorylmethyl)-3(2H)-furanones in good yields.Subse
Synthesis and Configurational Assignment of Geiparvarin: A Novel Antitumor Agent
Jerris, Paula J.,Smith, Amos B.
, p. 577 - 585 (2007/10/02)
This report presents the first total synthesis of geiparvarin as well as assignment of configuration of the previously undefined trisubstituted olefin.A central aspect of this synthetic adventure leading to this novel antitumor agent which possesses the 3
