74796-44-4Relevant academic research and scientific papers
New geiparvarin analogues from 7-(2-oxoethoxy)coumarins as efficient in vitro antitumoral agents
Chimichi, Stefano,Boccalini, Marco,Cosimelli, Barbara,Viola, Giampietro,Vedaldi, Daniela,Dall'Acqua, Francesco
, p. 7473 - 7476 (2007/10/03)
A new class of compounds analogues of geiparvarin is described: aldolic condensation of 3(2H)-furanones and 7-(2-oxoethoxy)coumarins followed by a very efficient dehydration protocol led to the title compounds which show good antitumoral activity against several human cell lines.
Synthesis and Configurational Assignment of Geiparvarin: A Novel Antitumor Agent
Jerris, Paula J.,Smith, Amos B.
, p. 577 - 585 (2007/10/02)
This report presents the first total synthesis of geiparvarin as well as assignment of configuration of the previously undefined trisubstituted olefin.A central aspect of this synthetic adventure leading to this novel antitumor agent which possesses the 3
