74805-92-8 Usage
Uses
Used in Pharmaceutical Industry:
Methylophiopogonanone A is used as a modulator of drug uptake for enhancing the cellular absorption of rosuvastatin and atorvastatin in HEK293T cells expressing human organic anion transporting polypeptide 1B1 (OATP1B1), potentially improving the efficacy of these statins.
Used in Antioxidant Applications:
Methylophiopogonanone A is used as a free radical scavenger for neutralizing 2,2-diphenyl-1-picrylhydrazyl (DPPH) and ABTS radicals in cell-free assays, which may contribute to its protective effects in various health conditions.
Used in Lipid Management:
Methylophiopogonanone A is used as a lipid-lowering agent for reducing serum and hepatic lipid levels in a rat model of high-fat diet-induced hyperlipidemia, suggesting its potential use in managing dyslipidemia.
Used in Cardiovascular Protection:
Methylophiopogonanone A is used as a cardioprotective agent for reducing infarct size and myocardial apoptosis in a mouse model of ischemia-reperfusion injury, indicating its potential role in protecting the heart from damage during ischemic events.
Check Digit Verification of cas no
The CAS Registry Mumber 74805-92-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,4,8,0 and 5 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 74805-92:
(7*7)+(6*4)+(5*8)+(4*0)+(3*5)+(2*9)+(1*2)=148
148 % 10 = 8
So 74805-92-8 is a valid CAS Registry Number.
InChI:InChI=1/C19H18O6/c1-9-16(20)10(2)19-15(17(9)21)18(22)12(7-23-19)5-11-3-4-13-14(6-11)25-8-24-13/h3-4,6,12,20-21H,5,7-8H2,1-2H3/t12-/m1/s1
74805-92-8Relevant academic research and scientific papers
Synthesis of methylophiopogonanone a
Katagiri, Ryo,Kiuchi, Fumiyuki,Narukawa, Yuji,Uekusa, Yoshinori
, p. 803 - 808 (2020/10/30)
Ophiopogon Root (root of Ophiopogon japonicus Ker-Gawler, Liliaceae) is a crude drug used as expectorant, anti-cough and tonic in Kampo medicine (traditional Japanese medicine) as well as other traditional medicines of Asian countries. It contains characteristic homoisoflavonoids with methylated ring A. We synthesized methylophiopogonanone A (1), which is a candidate marker compound for identification test of Ophiopogon Root, from phloroglucinol in 9 steps with overall yield of 11.1%.
Studies on the Constituents of Ophiopogonis Tuber. V. Isolation of a Novel Class of Homoisoflavonoids and Determination of Their Structures (1)
Tada, Akihiro,Kasai, Ryoji,Saitoh, Tamotsu,Shoji, Junzo
, p. 1477 - 1484 (2007/10/02)
New homoisoflavonoidal compounds, methylophiopogonanone A (Ia), methylophiopogonanone B (IIa), methylophiopogonone A (IIIa) and methylophiopogonone B (IVa), were isolated from ophiopogonis tubers (tubers of Ophiopogon japonicus KER-GAWLER var. genuinus MA
