74806-81-8Relevant academic research and scientific papers
Fumarase-Catalyzed Synthesis of L-threo-Chloromalic Acid and Its Conversion to 2-Deoxy-D-ribose and D-erythro-Sphingosine
Findeis, Mark A.,Whitesides, George M.
, p. 2838 - 2848 (2007/10/02)
This paper describes the use of pig heart fumarase (E.C. 4.2.1.2) as a catalyst in the multigram synthesis of L-threo-chloromalic acid (1) (>99.5percent enantiomeric excess) on 50-g scale.L-threo-Fluoromalic acid has been synthesized in a coupled enzymic system from difluorofumaric acid.Compound 1 serves as starting material for syntheses of 2-deoxy-D-ribose and D-erythro-sphingosine.
