7481-88-1

Basic information

• Product Name: ZALCITABINE RELATED COMPOUND A (50 MG) (2',3'-DIDEHYDRO-2',3'-DIDEOXYCYTIDINE)
• Synonyms: 2,3’-didehydro-2’,3’-dideoxy-cytidin;2’,3’-dideoxy-2’,3’-didehydrocytidine;ZALCITABINE RELATED COMPOUND A (50 MG) (2',3'-DIDEHYDRO-2',3'-DIDEOXYCYTIDINE);2',3'-dideoxycytidinene;1-(2,3-Dideoxy-β-D-glycero-2-pentenofuranosyl)-4-aminopyrimidin-2(1H)-one;2',3'-Didehydro-2',3'-dideoxycytidine;D4C;Dideoxycytidinene
• CAS NO: 7481-88-1
• Molecular Formula: C₉H₁₁N₃O₃
• Molecular Weight: 209.20194
• Product Categories: Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 7481-88-1.mol
• Article Data: 1

Chemical Properties

• Melting Point: 168-169℃ (ethanol )
• Boiling Point: 639.8°C at 760 mmHg
• Flash Point: 340.7°C
• Appearance: /
• Density: 1.56±0.1 g/cm3(Predicted)
• Vapor Pressure: 3.03E-17mmHg at 25°C
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: DMSO (Slightly), Ethanol (Slightly, Sonicated)
• PKA: 14.28±0.10(Predicted)
• Stability: Hygroscopic
• CAS DataBase Reference: ZALCITABINE RELATED COMPOUND A (50 MG) (2',3'-DIDEHYDRO-2',3'-DIDEOXYCYTIDINE)(CAS DataBase Reference)
• NIST Chemistry Reference: ZALCITABINE RELATED COMPOUND A (50 MG) (2',3'-DIDEHYDRO-2',3'-DIDEOXYCYTIDINE)(7481-88-1)
• EPA Substance Registry System: ZALCITABINE RELATED COMPOUND A (50 MG) (2',3'-DIDEHYDRO-2',3'-DIDEOXYCYTIDINE)(7481-88-1)

Safety Data

• Hazardous Substances Data: 7481-88-1(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 7481-88-1 differently. You can refer to the following data:
1. ZALCITABINE RELATED COMPOUND A (50 MG) (2',3'-DIDEHYDRO-2',3'-DIDEOXYCYTIDINE), can be used for the syntheis of Zalcitabine (Z140000), which is pyrimidine nucleoside analogue with antiviral activity.
2. Dideoxycytidinene, can be used for the synthesis of Zalcitabine (Z140000), which is pyrimidine nucleoside analogue with antiviral activity.

InChI:InChI=1/C9H11N3O3.C8H12N4O5/c10-7-3-4-12(9(14)11-7)8-2-1-6(5-13)15-8;9-6(16)7-10-2-12(11-7)8-5(15)4(14)3(1-13)17-8/h1-4,6,8,13H,5H2,(H2,10,11,14);2-5,8,13-15H,1H2,(H2,9,16)/t6-,8+;3-,4-,5-,8-/m01/s1

Upstream product

• 3056-17-5 stavudin 
• 65-46-3 CYTIDINE 

Downstream Products

• 73074-22-3 1-(2,3-dideoxy-5-O-p-tolylsulfonyl-β-D-glycero-pent-2-enofuranosyl)cytosine 
• 123413-57-0 N⁴-benzoyl-2',3'-didehydro-2',3'-dideoxycytidine 

Relevant articles and documents

Lactobacillus Fermentum N-Desoxyribosyl Transferases and the Use Thereof for Enzymatic Synthesis of 2', 3' - Didesoxynucleosides and 2',3'- Didehydro-2',3'- Didesoxynucleosides

The inventive method for evaluating an X protein encoded by an Lactobacillus fermentum (L. fermentum ) ntd gene in such a way that the characteristics thereof are modified consists a) in obtaining the Lactobacillus fermentum (L. fermentum ) ntd gene mutants by random mutagenesis, b) in transforming cells containing a [P-] phenotype provided with vectors containing mutated nucleic acids obtained at the stage a) coding for the thus modified X* proteins, wherein P- means that said cells are auxotrophic for a substance P produced by the action of X on a natural substrate S, c) in culturing said cells in a medium comprising a substrate S*, wherein S* is an analog to the natural substrate S of the protein X and d) in selecting the cells [P-::X*] which survived at the stage c) and ijn which the proteins X* are capable of carrying out the biosynthesis of the product P based on the substrate S*. The mutated L. fermentum N-desoxyribosyl transferases have an N-didesoxyribosyl transferase activity, corresponding nucleic acids, expression vectors, host cells containing said vectors and an application for the enzymatic synthesis of 2′,3′-didesoxynucleosides and 2′,3′-didehydro-2′,3′-didesoxynucleosides.