74815-20-6

Usage

Uses

Used in Pesticide Industry:
5,7-Dichloro-benzofuran-3-one is used as a pesticide for its ability to inhibit the growth of unwanted plants and insects. It functions by disrupting the synthesis of essential proteins in target organisms, ultimately leading to their death.
Used in Herbicide Industry:
In the herbicide industry, 5,7-Dichloro-benzofuran-3-one is utilized to control the proliferation of unwanted plant species. Its mode of action involves interfering with the protein production process in plants, which results in their controlled elimination.
Environmental Considerations:
Due to its moderately toxic nature to mammals, 5,7-Dichloro-benzofuran-3-one can have potential harmful effects on the liver and kidneys. Additionally, it poses a risk to aquatic organisms and has been recognized as a potential environmental contaminant. As a result, its use and disposal are subject to strict regulations in many countries to mitigate ecological and health risks.

Upstream product

• 15080-90-7 chloro-acetic acid-(2,4-dichloro-phenyl ester) 
• 120-83-2 2,4-dichlorophenol 
• 79214-30-5 2-chloro-1-(3,5-dichloro-2-hydroxyphenyl)ethanone 

Relevant academic research and scientific papers

Flavone inspired discovery of benzylidenebenzofuran-3(2H)-ones (aurones) as potent inhibitors of human protein kinase CK2

In this work, we describe the design, synthesis and SAR studies of 2-benzylidenebenzofuran-3-ones (aurones), a new family of potent inhibitors of CK2. A series of aurones have been synthesized. These compounds are structurally related to the synthetic flavones and showed nanomolar activities towards CK2. Biochemical tests revealed that 20 newly synthesized compounds inhibited CK2 with IC50 values in the nanomolar range. Further property-based optimization of aurones was performed, yielding a series of CK2 inhibitors with enhanced lipophilic efficiency. The most potent compound 12m (BFO13) has CLipE = 4.94 (CLogP = 3.5; IC50 = 3.6 nM) commensurable with the best known inhibitors of CK2.

As neuroprotective agents of pharmaceutical compounds

The invention discloses a medicinal compound as a neuroprotective agent. The medicinal compound is a neuronal nitric oxide synthase-postsynaptic density protein 95 (nNOS-PSD95) decoupling agent. The medicinal compound is a benzene ring derivative shown in the general formula (I) or its pharmaceutically acceptable salt. The invention further discloses a preparation method of the medicinal compound and a use of the medicinal compound in prevention and treatment on neuronal damage influence-caused diseases.