748151-77-1Relevant academic research and scientific papers
Hydrogen-bonded dimer can mediate supramolecular β-sheet formation and subsequent amyloid-like fibril formation: A model study
Banerjee, Arijit,Maji, Samir Kumar,Drew, Michael G.B.,Haldar, Debasish,Das, Apurba Kumar,Banerjee, Arindam
, p. 5935 - 5944 (2004)
FT-IR data of six terminally blocked tripeptides containing Acp (ε-aminocaproic acid) reveals that all of them form supramolecular β-sheets in the solid state. Single crystal X-ray diffraction studies of two peptides not only support this data but also disclose the fact that the supramolecular β-sheet formation is initiated via dimer formation. The Scanning Electron Microscopic images of all peptides exhibit amyloid-like fibrils that show green birefringence after binding with Congo red, which is a characteristic feature of many neurodegenerative disease causing amyloid fibrils.
