748185-47-9Relevant academic research and scientific papers
Synthesis of 6-vinyl and 5-vinylproline analogues of ascomycin
Bulusu, Murty A.R.C.,Waldst?tten, Peter,Tricotet, Thomas,Rochais, Christophe,Steck, Andrea,Bacher, Markus
, p. 5833 - 5836 (2007/10/03)
6-Vinyl (12) and (5R)- and (5S)-vinylproline (18, 19) analogues of ascomycin are synthesised starting from the known suitably protected (6S)-methoxy-9-hydroxy derivative (4) of ascomycin. The strategy involves hydrolytic cleavage of the Cε-N bond of the pipecolic acid moiety, extension of the amino acid side chain by two or one carbon units, functional group manipulations, Pd-catalysed reinstallation of the C ε-N or Cδ-N bonds, followed by deprotection and oxidation.
