74827-86-4

Basic information

• Product Name: 3',5'-dimethyl-2'-(ethylthio)-4'-hydroxyacetanilide
• CAS NO: 74827-86-4
• Molecular Weight: 239.338
• Mol File: 74827-86-4.mol

Chemical Properties

• CAS DataBase Reference: 3',5'-dimethyl-2'-(ethylthio)-4'-hydroxyacetanilide(CAS DataBase Reference)
• NIST Chemistry Reference: 3',5'-dimethyl-2'-(ethylthio)-4'-hydroxyacetanilide(74827-86-4)
• EPA Substance Registry System: 3',5'-dimethyl-2'-(ethylthio)-4'-hydroxyacetanilide(74827-86-4)

Safety Data

• Hazardous Substances Data: 74827-86-4(Hazardous Substances Data)

Upstream product

• 22900-79-4 N-(3,5-dimethyl-4-hydroxyphenyl)-acetamide 
• 13331-93-6 4-nitroso-2,6-xylenol 
• 74827-85-3 N-(3,5-dimethyl-4-oxocyclohexa-2,5-dien-1-ylidene)acetamide 
• 75-08-1 ethanethiol 

Relevant articles and documents

Studies on the mechanism of toxicity of acetaminophen. Synthesis and reactions of N-acetyl-2,6-dimethyl- and N-acetyl-3,5-dimethyl-p-benzoquinone imines

N-Acetyl-2,6-dimethyl-p-benzoquinone imine and N-acetyl-3,5-dimethyl-p-benzoquinone imine were prepared from 2,6-dimethylacetaminophen and 3,5-dimethylacetaminophen by oxidation with lead tetraacetate. Reaction of N-acetyl-2,6-dimethyl-p-benzoquinone imine with hydrochloric acid gave 3'-chloro-2',6'-dimethyl-4'-hydroxyacetanilide, whereas ethanethiol, aniline, and ethanol gave tetrahedral adducts resulting from addition to the imine carbon. Water gave 2,6-dimethyl-p-benzoquinone. With N-acetyl-3,5-dimethyl-p-benzoquinone imine, water and aniline gave substitution on the imine carbon, yielding 2,6-dimethyl-p-benzoquinone and 3,5-dimethyl-N-phenyl-p-benzoquinone imine, respectively. Ethanethiol gave 3',5'-dimethyl-2'-(ethylthio)-4'-hydroxyacetanilide. The toxicity of 2,6-dimethylacetaminophen and 3,5-dimethylacetaminophen was examined histologically in mice and rats. 3,5-Dimethylacetaminophen was slightly more nephrotoxic but showed a similar hepatotoxicity to acetaminophen. 2,6-Dimethylacetaminophen, like N-methylacetaminophen, showed very little tissue damage.