Welcome to LookChem.com Sign In|Join Free
  • or
Grahamimycin A1 is an unsymmetrical 14-membered macrocyclic dilactone antibiotic, synthesized through a formal total synthesis involving key intermediates such as (S)- and (R)-configured hydroxy acids and a methylenedioxyoctanoate derivative. The process employs strategic protecting groups like TBDMS and PTSE, followed by macrolactonization techniques (e.g., Yamaguchi procedure) to yield 11,12-dihydroxy-Grahamimycin A1, which is subsequently oxidized to the final product. The synthesis underscores the importance of stereochemical control, particularly at the C-6 position, to achieve the target structure.

74838-13-4

Post Buying Request

74838-13-4 Suppliers

Recommended suppliers

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

74838-13-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 74838-13-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,4,8,3 and 8 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 74838-13:
(7*7)+(6*4)+(5*8)+(4*3)+(3*8)+(2*1)+(1*3)=154
154 % 10 = 4
So 74838-13-4 is a valid CAS Registry Number.
InChI:InChI=1/C14H18O6/c1-9-4-3-5-13(17)20-10(2)8-12(16)11(15)6-7-14(18)19-9/h3,5,9-10H,4,6-8H2,1-2H3/b5-3-/t9-,10-/m1/s1

74838-13-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name (3Z,6R,14R)-6,14-dimethyl-1,7-dioxacyclotetradec-3-ene-2,8,11,12-tetrone

1.2 Other means of identification

Product number -
Other names Grahamimycin A(1)

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:74838-13-4 SDS

74838-13-4Relevant academic research and scientific papers

Total Synthesis of (-)-Grahamimycin A1

Hillis, Larry R.,Ronald, Robert C.

, p. 470 - 473 (2007/10/02)

A total synthesis of the novel antibiotic (-)-grahamimycin A1 (1) is described.The macrocycle 1 was prepared from the convergence of 5(R)-hydroxy-2(E)-hexanoate 2 and (R)-7-octynoic acid 3, both of which were readiy attainable from (R)-methylox

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1 Customer Service

What can I do for you?
Get Best Price

Get Best Price for 74838-13-4