74839-16-0Relevant academic research and scientific papers
Total Synthesis of the Urobiliverdin and Coprobiliverdin Isomers
Valasinas, Aldonia,Sambrotta, Luis,Diaz, Luis E.,Frydman, Benjamin
, p. 3001 - 3006 (2007/10/02)
The total synthesis of the five urobiliverdin isomers which can be derived from the oxidation of uroheme I and uroheme III was achieved, as well as the synthesis of the five coprobiliverdin isomers which can be derived from the oxidation of coproheme I an
Biosynthesis of Porphyrins and Related Macrocycles. Part 25. Synthesis of Analogues of Coproporphyrinogen-III and Studies of their Interaction with Copropophyrinogen-III Oxidase from Euglena gracilis
Robinson, John A.,McDonald, Edward,Battersby, Alan R.
, p. 1699 - 1710 (2007/10/02)
Analogues of coproporphyrinogen-III have been synthesized in which the propionate groups respectively on ring-A and on ring-B are modified either by homologation or esterification.Coproporphyrinogen-III oxidase from Euglena gracilis acts on the analogues which possess normal substituents on ring-A to generate a vinyl group on that ring.The enzyme does not affect the analogues in which the ring-A propionate group has been changed.Conditions have been defined for the MacDonald synthesis of porphyrins which yield products of high isomeric purity.
