74845-05-9Relevant academic research and scientific papers
One-pot synthesis of 2-aminoquinoline-based alkaloids from acetonitrile
Tomioka, Takashi,Takahashi, Yusuke,Maejima, Toshihide
experimental part, p. 5113 - 5118 (2012/08/07)
α-Diaminoboryl carbanions, readily prepared from acetonitrile, stereoselectively convert 2-nitrobenzaldehydes into nitrophenyl (Z)-acrylonitriles. Subsequent reductive cyclization leads to a series of 2-aminoquinoline derivatives. The entire procedure is practically operated in a single flask.
A short and versatile synthesis of 3-substituted 2-aminoquinolines
Compagnone, Reinaldo S.,Suarez, Alirica I.,Zambrano, Jorge L.,Pina, Ivette C.,Dominguez, Jose N.
, p. 1631 - 1641 (2007/10/03)
A short and versatile synthesis of a series of 3-substituted 2-aminoquinolines was accomplished in good yields starting from 2-nitrobenzaldehyde. Organic phosphonates were used as key synthetic intermediates and in some cases amino acids as readily available starting materials. The final two key steps of the sequence involving a reduction and ring closure that led to the 2-aminoquinoline skeleton were carried out in a 'one pot' procedure using SnCL22H2O.
