74851-58-4

Upstream product

• 684-93-5 1-methyl-1-nitrosourea 
• 42031-70-9 5-tert-butyl-2-oxocyclohexanecarboxylic acid 
• 98-53-3 4-tercbutyl-cyclohexanone 
• 616-38-6 carbonic acid dimethyl ester 

Downstream Products

• 74851-63-1 methyl trans-5-t-butyl-1-(p-methoxyphenyl)-2-oxocyclohexanecarboxylate 
• 74851-63-1 methyl 5-tert-butyl-2-cyclohexanone-1-p-methoxyphenyl-1-carboxylate 
• 98-53-3 4-tercbutyl-cyclohexanone 
• 87373-04-4 methyl cis-5-tert-butyl-1-methyl-2-oxocyclohexanecarboxylate 
• 22249-33-8 methyl trans-5-tert-butyl-1-methyl-2-oxocyclohexanecarboxylate 
• 87373-09-9 (1SR,2RS,4SR)-4-(tert-butyl)-2-(hydroxymethyl)-2-methylcyclohexan-1-ol 
• 87373-12-4 (1R,2S,4S)-4-tert-Butyl-2-hydroxymethyl-2-methyl-cyclohexanol 
• 87373-10-2 (1S,2S,4R)-4-tert-Butyl-2-hydroxymethyl-2-methyl-cyclohexanol 
• 87373-11-3 (1SR,2SR,4SR)-4-(tert-butyl)-2-(hydroxymethyl)-2-methylcyclohexan-1-ol 

Relevant academic research and scientific papers

Rh2(II)-catalyzed ester migration to afford 3 H-indoles from trisubstituted styryl azides

Rh2(II)-Complexes trigger the formation of 3H-indoles from ortho-alkenyl substituted aryl azides. This reaction occurs through a 4π-electron-5-atom electrocyclization of the rhodium N-aryl nitrene followed by a [1,2]-migration to afford only 3H-indoles. The selectivity of the migration is dependent on the identity of the β-styryl substituent.

Promoting reductive tandem reactions of nitrostyrenes with Mo(CO)6 and a palladium catalyst to produce 3 h -indoles

The combination of Mo(CO)6 and 10 mol % of palladium acetate catalyzes the transformation of 2-nitroarenes to 3H-indoles through a tandem cyclization-[1,2] shift reaction of in situ generated nitrosoarenes. Mo(CO)6 appears to have dual roles in this transformation: generate CO and promote C-N bond formation to increase the yield of the N-heterocycle product.

Total synthesis of (±)-paroxetine by diastereoconvergent cobalt-catalysed arylation

A total synthesis of paroxetine is reported, with a diastereoselective and diastereoconvergent cobalt-catalysed sp3-sp2 coupling reaction involving a 3-substituted 4-bromo-N-Boc-piperidine (Boc = tert-butoxycarbonyl) substrate as a key step. A 9:1 diastereoselectivity was obtained, while a control experiment involving a conformationally locked 3-substituted 4-bromo-tert-butyl cyclohexane ring proceeded with essentially complete stereoselectivity.

Highly diastereoselective formation of spirocyclic compounds via 1,5-hydrogen transfer: A total synthesis of (-)-erythrodiene

(Chemical Equation Presented) A highly stereoselective synthesis of (-)-erythrodiene starting from 4-isopropylcyclohexanone is described. The key reactions are an asymmetric methoxycarbonylation of the starting ketone and a highly diastereoselective radical cascade involving addition of a phenylthiyl radical to a terminal alkyne followed by a 1,5-hydrogen transfer and a 5-exo-cyclization.

Kinetics of Decarboxylation of the Two Epimers of 5-tert-Butyl-1-methyl-2-oxocyclohexanecarboxylic Acid: Lack of Stereoelectronic Control in β-Keto Acid Decarboxylation

Rates of decarboxylation of the two epimers of 5-tert-butyl-1-methyl-2-oxocyclohexanecarboxylic acid have been measured under both acidic and basic conditions at 25 deg C.The decomposition of isomer 1e (methyl and tert-butyl trans) is more rapid than that