74865-12-6

Basic information

• Product Name: 1-methoxy-2-(2-nitrophenoxy)benzene
• Synonyms: 1-(2-methoxyphenoxy)-2-nitrobenzene
• CAS NO: 74865-12-6
• Molecular Formula: C₁₃H₁₁NO₄
• Molecular Weight: 245.2307
• Mol File: 74865-12-6.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 348°C at 760 mmHg
• Flash Point: 147.7°C
• Density: 1.252g/cm³
• Vapor Pressure: 0.000104mmHg at 25°C
• Refractive Index: 1.588
• CAS DataBase Reference: 1-methoxy-2-(2-nitrophenoxy)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-methoxy-2-(2-nitrophenoxy)benzene(74865-12-6)
• EPA Substance Registry System: 1-methoxy-2-(2-nitrophenoxy)benzene(74865-12-6)

Safety Data

• Hazardous Substances Data: 74865-12-6(Hazardous Substances Data)

Usage

Classification

Organic compound, belongs to the group of nitrophenyl ethers.

Usage

Often used as an intermediate in the synthesis of various organic compounds, mainly as a precursor in the synthesis of pharmaceuticals, dyes, and other organic compounds.

Physical properties

Yellow solid at room temperature, insoluble in water, soluble in organic solvents.

Safety precautions

Potentially harmful if swallowed, inhaled, or in contact with skin; potentially explosive due to the presence of the nitro group, handle with extreme caution.

Upstream product

• 90-05-1 2-methoxy-phenol 
• 1493-27-2 ortho-nitrofluorobenzene 
• 577-19-5 2-nitrophenyl bromide 
• 5633-98-7 potassium guaiacolate 
• 88-73-3 2-Chloronitrobenzene 

Downstream Products

• 22751-09-3 2-amino-2'-methoxydiphenyl ether 
• 873985-02-5 1-methoxy-4-nitro-2-(2-nitro-phenoxy)-benzene 
• 860603-35-6 4-chloro-1-methoxy-2-(2-nitro-phenoxy)-benzene 
• 860603-13-0 1,2-dichloro-4-methoxy-5-(2-nitro-phenoxy)-benzene 
• 860603-78-7 4-bromo-1-methoxy-2-(2-nitro-phenoxy)-benzene 
• 860519-27-3 1-bromo-2-(2-methoxyphenoxy)benzene 
• 91569-24-3 2-(2-aminophenoxy)-phenol 
• 54291-84-8 2-hydroxy-2'-nitrodiphenyl ether 

Relevant articles and documents

Design, synthesis and antifungal activity of novel furancarboxamide derivatives

Twenty-seven novel furancarboxamide derivatives with a diphenyl ether moiety were synthesized and evaluated for their antifungal activity against Rhizoctonia solani, Botrytis cirerea, Valsa Mali and Sphaceloma ampelimum. Antifungal bioassay results indicated that most compounds had good or excellent fungicidal activities for R. solani and S. ampelimum at 20 mg L-1. Among synthesized compounds, compound 18e showed a greater inhibitory effect against S. ampelimum, with half maximal effective concentration (EC50) values of 0.020 mg L-1. This strong activity rivals currently used commercial fungicides, such as Boscalid and Carbendazim, and has great potential as a lead compound for future development of novel fungicides.

A Fast Way to Fluorescence: A Fourfold Domino Reaction to Condensed Polycyclic Compounds

A fast and efficient palladium-catalyzed fourfold domino Sonogashira/double-carbopalladation/C H-activation reaction that converts simple aromatic systems into complex polycyclic hydrocarbons has been developed. A number of substituted products has thus been prepared in yields up to 89 %. The structural assignment has been confirmed by using single-crystal X-ray crystallography. The products show intriguing fluorescence activity and thus might serve as chemical sensors or fluorescent imaging dyes.

Synthesis, Activity, and Molecular Modeling Studies of Novel Human Aldose Reductase Inhibitors Based on a Marine Natural Product

Aldose reductase (ALR2) has been implicated in the etiology of diabetic complications, including blindness. Because of the limited number of currently available drugs for the prevention of these long-term complications, the discovery of new ALR2 inhibitor