74867-82-6Relevant academic research and scientific papers
Novel synthetic oleanane and ursane triterpenoids with various enone functionalities in ring A as inhibitors of nitric oxide production in mouse macrophages
Honda, Tadashi,Gribble, Gordon W.,Suh, Nanjoo,Finlay, Heather J.,Rounds, BarbieAnn V.,Bore, Lothar,Favaloro Jr., Frank G.,Wang, Yongping,Sporn, Michael B.
, p. 1866 - 1877 (2007/10/03)
We initially randomly synthesized about 60 oleanane and ursane triterpenoids as potential anti-inflammatory and cancer chemopreventive agents. Preliminary screening of these derivatives for inhibition of production of nitric oxide induced by interferon-γ in mouse macrophages revealed that 3-oxooleana-1,12-dien-28-oic acid (B-15) showed significant activity (IC50 = 5.6/μM). On the basis of the structure of B-15, 19 novel olean- and urs-12-ene triterpenoids with a 1-en-3-one functionality having a substituent at C-2 in ring A have been designed and synthesized. Among them, 3-oxooleana-1,12-diene derivatives with carboxyl, methoxycarbonyl, and nitrile groups at C-2 showed higher activity than the lead compound B-15. In particular, 2-carboxy-3-oxooleana-1,12-dien-28-oic acid (3) had the highest activity (IC50 = 0.07/μM) in this group of triterpenoids. The potency of 3 was similar to that of hydrocortisone (IC50 = 0.01/μM), although 3 does not act through the glucocorticoid receptor. Interesting structure-activity relationships of these novel synthetic triterpenoids are also discussed.
Novel synthetic oleanane triterpenoids: A series of highly active inhibitors of nitric oxide production in mouse macrophages
Honda, Tadashi,Rounds, BarbieAnn V.,Bore, Lothar,Favaloro Jr., Frank G.,Gribble, Gordon W.,Suh, Nanjoo,Wang, Yongping,Sporn, Michael B.
, p. 3429 - 3434 (2007/10/03)
Novel oleanane triterpenoids with modified rings A and C were designed and synthesized. Among them, methyl 2-carboxy-3,12-dioxooleana-1,9-dien-28-oate showed similar high inhibitory activity (IC50 = 0.8 nM) to 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO), which we have synthesized previously, against production of nitric oxide induced by interferon-γ in mouse macrophages.
