74874-07-0

Usage

Uses

Used in Pharmaceutical Industry:
[2R-[1(S),2alpha,4beta]]-1-[2-[[(1,1-Dimethylethoxy)carbonyl]amino]-5-[[imino(nitroamino)methyl]amino]-1-oxopentyl]-4-methyl-2-piperidinecarboxylic acid ethyl ester is used as a potential drug candidate for its intricate molecular structure that may offer specific therapeutic effects. The presence of various functional groups could allow it to interact with biological targets in unique ways, making it a candidate for the development of new medications.
Used in Biochemical Research:
In the field of biochemical research, [2R-[1(S),2alpha,4beta]]-1-[2-[[(1,1-Dimethylethoxy)carbonyl]amino]-5-[[imino(nitroamino)methyl]amino]-1-oxopentyl]-4-methyl-2-piperidinecarboxylic acid ethyl ester may serve as a tool compound for studying the interactions between complex molecules and biological systems. Its unique structure could provide insights into new mechanisms of action or reveal novel biochemical pathways.
Used in Chemical Process Industry:
[2R-[1(S),2alpha,4beta]]-1-[2-[[(1,1-Dimethylethoxy)carbonyl]amino]-5-[[imino(nitroamino)methyl]amino]-1-oxopentyl]-4-methyl-2-piperidinecarboxylic acid ethyl ester could be utilized as a component in specialized chemical processes, where its specific functional groups may facilitate targeted reactions or improve the efficiency of certain processes.

Upstream product

• 66937-93-7 4(R)-Methylpiperidine-2(R)-carboxylic acid ethyl ester 
• 42205-75-4 ethyl trans-(±)-4-methylpiperidine-2-carboxylate 
• 2188-18-3 Boc-Arg(NO₂)-OH 
• 74892-82-3 ethyl (2R-trans)-4-methylpiperidine-2-carboxylate 
• 42205-75-4 ethyl trans-4-methylpiperidine-2-carboxylate 
• 85796-64-1 2,3,4,5-tetrahydro-4-methylpyridine 
• 626-58-4 4-methylpiperidin 
• 2188-18-3 N-alpha-t-butoxycarbonyl-Ng-nitroarginine 

Downstream Products

• 69129-28-8 ethyl 4-methyl-1-(N^ω-nitro-L-arginyl)piperidinecarboxylate hydrochloride 

Relevant academic research and scientific papers

PROCESS INTERMEDIATES AND METHODS FOR THE PREPARATION OF PROCESS INTERMEDIATES FOR THE SYNTHESIS OF ARGATROBAN MONOHYDRATE

Methods are provided for the synthesis of key intermediates for the synthesis of Argatroban monohydrate, ethyl (2R,4R)-1-[(2S)-2-amino-5-[[imino(nitroamino)methyl]amino]-1-oxopentyl]-4-methylpiperidine-2-carboxylate compounded with HCl. Such intermediates are also provided.

METHOD FOR THE PREPARATION OF PROCESS INTERMEDIATES FOR THE SYNTHESIS OF ARGATROBAN MONOHYDRATE

Object of the present invention is a method for the synthesis of a key intermediate for the synthesis of Argatroban monohydrate, ethyl (2R,4R)-1-[(2S)-2-amino-5-[[imino(nitroamino)methyl]amino]-1-oxopentyl]-4- methylpiperidine-2-carboxylate compounded with HCl.

Thrombin inhibitors. 3. Carboxyl-containing amide derivatives of N alpha-substituted L-arginine.

A series of N alpha-(arylsulfonyl)-L-arginine amide derivatives having carboxamide N-substituents with a carboxyl group was prepared and tested as inhibitors of the clotting activity of thrombin. The most inhibitory compounds were obtained when a carboxyl group was introduced into the carbon next to the amide nitrogen of N alpha-(arylsulfonyl)-L-arginine amide derivatives, e.g., N alpha-(arylsulfonyl)-L-arginyl-N-butyl-, N-(methoxyethyl)- or N-(tetrahydrofurfuryl)glycine and 4-alkyl-1-[N alpha-(arylsulfonyl)-L-arginyl]-2-piperidinecarboxylic acid, with an I50 of 1-3 X 10(-7) M.