74874-08-1

Basic information

• Product Name: Ethyl (2R,4R)-1-(Nitroglycerine-nitro-L-arginyl)-4-methyl-piperidinecarboxylate hydrochloride
• Synonyms: Ethyl (2R,4R)-1-(Nitroglycerine-nitro-L-arginyl)-4-methyl-piperidinecarboxylate hydrochloride;[2R-[1(S*),2α,4β]] -1-[2-amino-5-[[imino(nitroamino)methyl]amino]-1-oxopentyl];Argatroban Intermediate;Ethyl (2R,4R)-1-[2-amino-5-[[imino(nitroamino)methyl]amino]-1-oxopentyl]-4-methyl-2-piperidinecarboxylate hydrochloride;[2R-[1(S*),2,4]] -1-[2-amino-5-[[imino(nitroamino)methyl]amino]-1-oxopentyl]4-methyl-2-Piperidinecarboxylic acid ethyl ester, monohydrochloride;1-[2-Amino-5-[[imino(nitroamino)methyl]amino]-1-oxopentyl]-4-methyl-2-piperidinecarboxylic Acid Ethyl Ester Hydrochloride;(2R,4R)-ETHYL 1-(S)-AMINO-5-(3-NITROGUANIDINO) PENTANOYL-4-METHYLPIPERIDINE-2-CARBOXYLATE HYDROCHLORIDE;(2R,4R)-Ethyl 1-(2-amino-5-(3-nitroguanidino)pentanoyl)-4-methylpiperidine-2-carboxylate hydrochl
• CAS NO: 74874-08-1
• Molecular Formula: C₁₅H₂₈N₆O₅*ClH
• Molecular Weight: 408.88
• EINECS: 1312995-182-4
• Product Categories: Amines;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds
• Mol File: 74874-08-1.mol
• Article Data: 1

Chemical Properties

• Melting Point: 174-177°C
• Appearance: /
• Storage Temp.: -20°C Freezer
• Solubility: DMSO, Methanol
• Stability: Hygroscopic
• CAS DataBase Reference: Ethyl (2R,4R)-1-(Nitroglycerine-nitro-L-arginyl)-4-methyl-piperidinecarboxylate hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl (2R,4R)-1-(Nitroglycerine-nitro-L-arginyl)-4-methyl-piperidinecarboxylate hydrochloride(74874-08-1)
• EPA Substance Registry System: Ethyl (2R,4R)-1-(Nitroglycerine-nitro-L-arginyl)-4-methyl-piperidinecarboxylate hydrochloride(74874-08-1)

Safety Data

• Hazardous Substances Data: 74874-08-1(Hazardous Substances Data)

Usage

Chemical Properties

Off White Solid

Uses

Argatroban intermediate.

InChI:InChI=1/C15H28N6O5.ClH/c1-3-26-14(23)12-9-10(2)6-8-20(12)13(22)11(16)5-4-7-18-15(17)19-21(24)25;/h10-12H,3-9,16H2,1-2H3,(H3,17,18,19);1H/t10-,11?,12-;/m1./s1

Upstream product

• 2188-18-3 Boc-Arg(NO₂)-OH 
• 66937-93-7 4(R)-Methylpiperidine-2(R)-carboxylic acid ethyl ester 
• 74863-81-3 ethyl 1-α-(tert-butoxycarbonyl)-N^ω-nitro-L-arginyl>-4-methyl-2-piperidinecarboxylate 

Relevant articles and documents

Thrombin inhibitors. 3. Carboxyl-containing amide derivatives of N alpha-substituted L-arginine.

A series of N alpha-(arylsulfonyl)-L-arginine amide derivatives having carboxamide N-substituents with a carboxyl group was prepared and tested as inhibitors of the clotting activity of thrombin. The most inhibitory compounds were obtained when a carboxyl group was introduced into the carbon next to the amide nitrogen of N alpha-(arylsulfonyl)-L-arginine amide derivatives, e.g., N alpha-(arylsulfonyl)-L-arginyl-N-butyl-, N-(methoxyethyl)- or N-(tetrahydrofurfuryl)glycine and 4-alkyl-1-[N alpha-(arylsulfonyl)-L-arginyl]-2-piperidinecarboxylic acid, with an I50 of 1-3 X 10(-7) M.