748772-86-3

Upstream product

• 88-75-5 2-hydroxynitrobenzene 
• 748771-95-1 2-isopropoxyaniline hydrochloride 
• 38753-50-3 1-isopropoxy-2-nitrobenzene 
• 29026-74-2 2-isopropoxy-phenylamine 
• 52178-50-4 Methyl 3-formylbenzoate 
• 614747-33-0 N'-(2-isopropoxy-phenyl)-ethane-1,2-diamine 

Relevant academic research and scientific papers

Aryl piperidine amides

The invention provides novel GlyT2 inhibiting compounds useful in modulating, treating, or preventing: anxiolytic disorders; a condition requiring treatment of injured mammalian nerve tissue; a condition amenable to treatment through administration of a neurotrophic factor; a neurological disorder; or obesity; an obesity-related disorder.

Inhibitors of the glycine transporter type-2 (GlyT-2): synthesis and biological activity of benzoylpiperidine derivatives.

A series of benzoylpiperidine analogs related to 4a was prepared, and their ability to inhibit the uptake of [(14)C]-glycine in COS7 cells transfected with human glycine transporter type-2 (GlyT-2) was evaluated. Small structural changes to the benzoylpiperidine region of the molecule led to a significant decrease in GlyT-2 inhibitory activity. In contrast, the distal aryl ring was more tolerant to functional group modifications and could accommodate a variety of substitutes at the C-2 or C-3 positions. Comparable activities to 4a were obtained by replacing the anilino nitrogen with an ether linkage 27 or by exchanging the isopropoxy ether moiety with an isopropyl amino group 15. A distinct preference for a 2-carbon tether (n=1) was observed relative to the corresponding 3-carbon homolog (n=2).