748804-13-9Relevant academic research and scientific papers
Proton-coupled electron transfer from tyrosine: A strong rate dependence on intramolecular proton transfer distance
Zhang, Ming-Tian,Irebo, Tania,Johansson, Olof,Hammarstroem, Leif
supporting information; experimental part, p. 13224 - 13227 (2011/10/10)
Proton-coupled electron transfer (PCET) was examined in a series of biomimetic, covalently linked RuII(bpy)3-tyrosine complexes where the phenolic proton was H-bonded to an internal base (a benzimidazyl or pyridyl group). Photooxidation in laser flash/quench experiments generated the RuIII species, which triggered long-range electron transfer from the tyrosine group concerted with short-range proton transfer to the base. The results give an experimental demonstration of the strong dependence of the rate constant and kinetic isotope effect for this intramolecular PCET reaction on the effective proton transfer distance, as reflected by the experimentally determined proton donor-acceptor distance.
Synthesis of tyrosine derivatives for saframycin MX1 biosynthetic studies
Schmidt, Eric W.,Nelson, James T.,Fillmore, John P.
, p. 3921 - 3924 (2007/10/03)
Saframycin MX1 and structural relatives are natural anticancer agents isolated from bacteria and marine invertebrates. For biosynthetic studies and to make a library of modified natural products, a series of tyrosine derivatives were synthesized in a conc
