748805-85-8

Basic information

• Product Name: 2-AMINO-5-CHLOROBENZYL ALCOHOL
• Synonyms: RARECHEM AL BD 1516;2-AMINO-5-CHLOROBENZYL ALCOHOL;(2-AMINO-5-CHLOROPHENYL)METHANOL;4-Fluoro-2-hydroxymethylaniline;2-AMINO-5-CHLOROBENZYL ALCOHO
• CAS NO: 748805-85-8
• Molecular Formula: C₇H₈FNO
• Molecular Weight: 157.6
• Mol File: 748805-85-8.mol
• Article Data: 22

Chemical Properties

• Melting Point: 107-109 °C(lit.)
• Boiling Point: 286 °C at 760 mmHg
• Flash Point: 126.8 °C
• Appearance: /
• Density: 1.286 g/cm³
• Storage Temp.: Room temperature.
• CAS DataBase Reference: 2-AMINO-5-CHLOROBENZYL ALCOHOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-5-CHLOROBENZYL ALCOHOL(748805-85-8)
• EPA Substance Registry System: 2-AMINO-5-CHLOROBENZYL ALCOHOL(748805-85-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• Hazardous Substances Data: 748805-85-8(Hazardous Substances Data)

Usage

General Description

2-AMINO-5-CHLOROBENZYL ALCOHOL, also known as 2-amino-5-chlorobenzyl alcohol, is a chemical compound with the molecular formula C7H8ClNO. It is a white crystalline solid that is commonly used in organic synthesis and as a building block in the production of pharmaceuticals and agrochemicals. 2-AMINO-5-CHLOROBENZYL ALCOHOL has a variety of applications, including as a precursor for the synthesis of heterocyclic compounds and as a reagent for the preparation of optically active amines. Additionally, it has been investigated for its potential use in the treatment of various diseases and disorders due to its pharmacological properties.

Upstream product

• 395-81-3 5-fluoro-2-nitrobenzaldehyde 
• 287121-32-8 (5-Fluoro-2-nitrophenyl)-methanol 
• 446-08-2 2-amino-5-fluorobenzoic acid 

Downstream Products

• 1026623-51-7 4-(4-fluoro-2-hydroxymethyl-phenylamino)-piperidine-1-carboxylic acid tert-butyl ester 
• 1428747-29-8 8-fluoro-12-(4-fluorophenyl)-4b,6-dihydrobenzo[4,5][1,3]oxazino[2,3-a]isoquinoline 
• 1428747-18-5 8-fluoro-12-phenyl-4b,6-dihydrobenzo[4,5][1,3]oxazino[2,3-a]isoquinoline 
• 146829-56-3 2-amino-5-fluoro benzaldehyde 
• 934522-06-2 2,2'-selenobis(5-fluorobenzyl alcohol) 
• 137595-45-0 3-Phenyl-6-fluoroquinoline 
• 690664-26-7 C₁₀H₁₀FNO₂ 
• 42835-89-2 6-fluoro-1,2,3,4-tetrahydro-2-methylquinoline 
• 1128-61-6 6-fluoro-2-methyl-quinoline 
• 2558-26-1 6-fluoro-2-phenylquinoline 

Relevant articles and documents

Construction of a benzo[b]azepine skeleton through decarboxylative ylide [6+1] annulations with modified vinyl benzoxazinanones

A Lewis acid-promoted [6+1] annulation between sulfur ylides and modified vinyl benzoxazinanones was described. In this reaction, the newly designed vinyl benzoxazinanones could serve as a novel six-atom synthon, and the key to success is the installation of an electron-withdrawing group on the alkene moiety of the benzoxazinanones. A broad range of substrates are compatible with this mild reaction system, thereby providing a facile and practical approach for constructing a benzo[b]azepine skeleton.

A [4+3] Cycloaddition Reaction of Aza-ortho-quinone Methides with C,N-Cyclic Azomethine Imines for Synthesis of 1,2,4-Triazepines

The base-induced formal [4+3] cycloaddition reaction of C,N-cyclic azomethine imines with aza-ortho-quinone methides, generated in situ, is reported. This protocol provided an efficient method for the synthesis of biologically important 1,2,4-triazepine derivatives, with a wide substrate scope and excellent functional-group tolerance, and it gives moderate to excellent yields under mild conditions. Several of the derivatives exhibited in vitro antitumor activities against the A2780 cell line in a screening of the cancer cell lines HCT-116, H2228, and A2780 by an MTT assay.

Benzoazepine-Fused Isoindolines via Intramolecular (3 + 2)-Cycloadditions of Azomethine Ylides with Dinitroarenes

Aminobenzaldehydes bearing a pendant 3,5-dinitrophenyl group react thermally with N-substituted α-amino acids to form unprecedented benzoazepine-fused isoindolines. The reaction proceeds via a dearomatization/rearomatization sequence involving an intramolecular (3 + 2)-cycloaddition between the in situ formed azomethine ylide and the dinitroarene. Various glycine derivatives are tolerated as well as branched substrates based on cyclic, α-mono-, and α,α-disubstituted amino acids, giving single diastereomers in many cases. The method is scalable and gives products with a nitro group ready for further manipulation.