748813-14-1Relevant academic research and scientific papers
Imidazole acetic acid TAFIa inhibitors: SAR studies centered around the basic P′1 group
Nantermet, Philippe G.,Barrow, James C.,Lindsley, Stacey R.,Young, Marybeth,Mao, Shi-Shan,Carroll, Steven,Bailey, Carolyn,Bosserman, Michele,Colussi, Dennis,McMasters, Daniel R.,Vacca, Joseph P.,Selnick, Harold G.
, p. 2141 - 2145 (2007/10/03)
Structural modifications of the aminopyridine P1 ′ group of imidazole acetic acid based TAFIa inhibitors led to the discovery of the aminocyclopentyl analog 28, a 1nM TAFIa inhibitor with CLT50 functional activity of 14nM but without selectivity against CPB. While not as active, aminobutyl derivative 27 provided an improved 6.7-fold selectivity for TAFIa versus CPB.
