74889-31-9Relevant academic research and scientific papers
Discovery of a new binding mode for a series of liver X receptor agonists
Kopecky, David J.,Jiao, Xian Yun,Fisher, Ben,McKendry, Sharon,Labelle, Marc,Piper, Derek E.,Coward, Peter,Shiau, Andrew K.,Escaron, Patrick,Danao, Jean,Chai, Anne,Jaen, Juan,Kayser, Frank
scheme or table, p. 2407 - 2410 (2012/05/05)
Structural modification of a series of dual LXRα/β agonists led to the identification of a new class of LXRβ partial agonists. An X-ray co-crystal structure shows that a representative member of this series, pyrrole 5, binds to LXRβ with a reversed orient
Products from N-Substituted Pyrroles and Trifluoroacetic Anhydride: Ratios and Conformations of Isomers
Chadwick, Derek J.,Meakins, G. Denis,Rhodes, Caroline A.
, p. 878 - 886 (2007/10/02)
A series of N-substituted pyrroles has been treated with trifluoroacetic anhydride.Small alkyl groups or aryl groups (as the N-substituents) lead exclusively, or almost exclusively, to the 2-trifluoroacetyl derivatives, bulky groups (notably 1-adamantyl) to the 3-derivatives, and those of intermediate size (such as i-propyl) to mixtures of isomers.N-Substituted 3-trifluoroacetylpyrroles exist in solution as mixtures of rotational isomers whereas the 2-isomers adopt a preferred conformation in which the nitrogen and oxygen atoms are in the syn orientation.
