749151-25-5Relevant academic research and scientific papers
Further exploration of the structure-activity relationship of dual soluble epoxide hydrolase/fatty acid amide hydrolase inhibitors
Wilt, Stephanie,Kodani, Sean,Valencia, Leah,Hudson, Paula K.,Sanchez, Stephanie,Quintana, Taylor,Morisseau, Christophe,Hammock, Bruce D.,Kandasamy, Ram,Pecic, Stevan
, (2021/11/19)
Fatty acid amide hydrolase (FAAH) is a membrane protein that hydrolyzes endocannabinoids, and its inhibition produces analgesic and anti-inflammatory effects. The soluble epoxide hydrolase (sEH) hydrolyzes epoxyeicosatrienoic acids (EETs) to dihydroxyeico
Synthesis and evaluation of benzothiazole-Based analogues as novel, potent, and selective fatty acid amide hydrolase inhibitors
Wang, Xueqing,Sarris, Katerina,Kage, Karen,Zhang, Di,Brown, Scott P.,Kolasa, Teodozyi,Surowy, Carol,El Kouhen, Odile F.,Muchmore, Steven W.,Brioni, Jorge D.,Stewart, Andrew O.
experimental part, p. 170 - 180 (2009/08/07)
High-throughput screening (HTS) identified benzothiazole analogue 3 as a potent fatty acid amide hydrolase (FAAH) inhibitor. Structure-activity relationship (SAR) studies indicated that the sulfonyl group, the piperidine ring and benzothiazole were the ke
