74917-81-0

Basic information

• Product Name: 6-[(2E)-2-(3-methyl-4-nitroisoxazol-5(2H)-ylidene)ethylidene]cyclohexa-2,4-dien-1-one
• CAS NO: 74917-81-0
• Molecular Formula: C₁₂H₁₀N₂O₄
• Molecular Weight: 246.2188
• Mol File: 74917-81-0.mol

Chemical Properties

• Boiling Point: 359.6°C at 760 mmHg
• Flash Point: 171.3°C
• Density: 1.37g/cm³
• Vapor Pressure: 2.35E-05mmHg at 25°C
• Refractive Index: 1.632
• CAS DataBase Reference: 6-[(2E)-2-(3-methyl-4-nitroisoxazol-5(2H)-ylidene)ethylidene]cyclohexa-2,4-dien-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-[(2E)-2-(3-methyl-4-nitroisoxazol-5(2H)-ylidene)ethylidene]cyclohexa-2,4-dien-1-one(74917-81-0)
• EPA Substance Registry System: 6-[(2E)-2-(3-methyl-4-nitroisoxazol-5(2H)-ylidene)ethylidene]cyclohexa-2,4-dien-1-one(74917-81-0)

Safety Data

• Hazardous Substances Data: 74917-81-0(Hazardous Substances Data)

Upstream product

• 1123-49-5 3,5-dimethyl-4-nitroisoxazole 
• 90-02-8 salicylaldehyde 
• 89-95-2 2-methyl-benzyl alcohol 

Downstream Products

• 114650-01-0 Acetic acid 2-[1-(3-methyl-4-nitro-isoxazol-5-ylmethyl)-3-oxo-3-phenyl-propyl]-phenyl ester 
• 1262968-91-1 1-(2-hydroxyphenyl)-2-(3-methyl-4-nitroisoxazol-5-yl)ethanesulfonic acid 
• 1253520-21-6 C₁₂H₁₀N₂O₂ 
• 1253520-25-0 2-{2-(3-methyl-4-nitro-5-isoxazolyl)-1-[(3-methyl-4-nitro-5-isoxazolyl)methyl]ethyl}phenol 
• 80610-12-4 3,5-dimethyl-7-(o-hydroxyphenyl)-7,8-dihydro-6H-isoxazolo<7,8-b>azepine 
• 114650-07-6 ethyl α-carbethoxy-β-(o-hydroxyphenyl)-γ-(3-methyl-4-nitro-5-isoxazolyl)-n-butyrate 
• 80610-07-7 Acetic acid 2-[1-(3-methyl-4-nitro-isoxazol-5-ylmethyl)-3-oxo-butyl]-phenyl ester 
• 114650-08-7 α-carbethoxy-β-(o-hydroxyphenyl)-γ-(3-methyl-4-nitro-5-isoxazolyl)-n-butyronitrile 
• 77533-56-3 2-[(E)-2-(4-Amino-3-methyl-isoxazol-5-yl)-vinyl]-phenol 
• 114650-06-5 4-o-ethoxycarbonyloxyphenyl-5-(3-methyl-4-nitro-5-isoxazolyl)-2-pentanone 

Relevant articles and documents

Synthesis of 4H-chromene-isoxazole hybrids via ortho-hydroxy directing cyclization of isoxazole-styrenes and Michael addition of imino-chromenes in aqueous medium

A green, efficient, and one-pot method synthesis of functionalized 4H-chromene-isoxazole hybrids is reported via o-hydroxy group directing cyclization of isoxazole-styrenes and Michael addition of 3,5-dimethyl-4-nitroisoxazole on 2-imino-2H-chromene-3-carbonitrile (independent methods). The developed methodology was further extended for nitromethane, malononitrile, and alkylcyanoacetates as Michael donors.

One-pot synthesis of functionalized isoxazole-thiolane hybrids via Knoevenagel condensation and domino sulfa-1,6-Michael/intramolecular vinylogous Henry reactions

One-pot synthesis of highly functionalized tetrahydrothiophene (thiolane) derivatives conjugated with biologically useful isooxazole are reported via the Knoevenagel condensation followed by domino sulfa-1,6-Michael/intramolecular vinylogous Henry reactio

A fast and highly efficient protocol for synthesis of pyrrolo[2,3-d] isoxazoles and a new series of novel benzyl bis-pyrrolo[2,3-d]isoxazoles using task-specific ionic liquids as catalyst and green solvent

We report a mild, fast, highly efficient and eco-friendly protocol for the green synthesis of pyrrolo[2,3-d]isoxazoles and a new series of novel benzyl bis-pyrrolo[2,3-d]isoxazoles from nitro styrylisoxazoles in SnCl 2-ionic liquid by reductive

Michael additions on isoxazole derivatives under solvent-free conditions

Knoevenagel condensation of 3,5-dimethyl-4-nitro-isoxazole 1 with aromatic aldehydes in solid state in the presence of piperidine gives 3-methyl-4-nitro-5-styryl-isoxazoles 2 in excellent yields within few minutes. Michael addition of active methylene com

Fused Heterocycles. IV. Synthesis of 7-(o-Hydroxyphenyl)-3,5-dimethyl-7,8-dihydro-6H-isoxazoloazepines

Michael addition of acetylacetone to 3-methyl-4-nitro-5-(o-hydroxystyryl)isoxazoles gives 4-(o-acetoxyphenyl)-5-(3-methyl-4-nitro-5-isoxazoyl)-2-pentanones (4).Reductive cyclization of 4 with tin(II) chloride and concentrated hydrochloric acid leads to 7-