74917-83-2

Upstream product

• 1123-49-5 3,5-dimethyl-4-nitroisoxazole 
• 135-02-4 ortho-anisaldehyde 

Downstream Products

• 1370018-88-4 7,7'-(2-methoxyphenylmethylene)bis(3-methyl-6-phenylisoxazolo[4,5-b]pyridine-N-oxide) 
• 1371645-11-2 (+)-dimethyl 2-(2-methoxyphenyl)-3-(3-methyl-4-nitroisoxazol-5-yl)cyclopropane-1,1-dicarboxylate 
• 1334145-75-3 (S)-5-(2-(2-methoxyphenyl)-2-(phenylthio)ethyl)-3-methyl-4-nitroisoxazole 
• 1380544-34-2 5-(2-methoxyphenethyl)-3-methyl-4-nitroisoxazole 
• 77533-57-4 5-[(E)-2-(2-Methoxy-phenyl)-vinyl]-3-methyl-isoxazol-4-ylamine 

Relevant academic research and scientific papers

Phosphine-Catalyzed [3 + 2] Annulation of Morita-Baylis-Hillman Carbonates with Isoxazole-Based Alkenes

A phosphine-catalyzed [3 + 2] annulation of Morita-Baylis-Hillman (MBH) carbonates with 3-methyl-4-nitro-5-styrylisoxazoles has been developed to afford various multifunctional isoxazoles in moderate to good yields with moderate to excellent diastereoselectivities. With a spirocyclic chiral phosphine as the catalyst, up to 89% ee was obtained.

Catalytic enantioselective addition of isocyanoacetate to 3-methyl-4-nitro-5-styrylisoxazoles under phase transfer catalysis conditions

The reaction between 3-methyl-4-nitro-5-styrylisoxazoles and ethyl isocyanoacetate proceeded under phase transfer catalysis to give enantioenriched monoadducts in high enantiomeric excess (up to 99% ee). The resulting adducts were subsequently cyclised to give 2,3-dihydropyrroles and substituted pyrrolidines in identical high ees and as a single diastereoisomer.

Multi-component synthesis and in vitro and in vivo anticancer activity of novel arylmethylene bis-isoxazolo[4,5-b]pyridine-N-oxides

A three component one-pot protocol has been investigated for the synthesis of arylmethylene bis-isoxazolo[4,5-b]pyridine-N-oxides 1 from the commercially available materials. The title compounds 1 were also synthesized by a step-wise method and found to b