749174-88-7Relevant academic research and scientific papers
Sulphonamidocycloalkane compounds, pharmaceutical compositions containing them, and methods of use thereof
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, (2008/06/13)
The present invention provides sulphonamides of the general formula: STR1 wherein R1 and R2, which can be the same or different, are hydrogen or halogen atoms or C1 -C6 -alkyl, trifluoro-methyl, cyano, carboxyl, alkoxycarbonyl, aminocarbonyl, N-alkylaminocarbonyl or N,N-dialkylaminocarbonyl radicals or, when R1 and R2 are alkyl radicals ortho to one another, R1 and R2, together with the carbon atoms to which they are attached, form a saturated or unsaturated C5 -C7 -alkylene ring, R3 is a hydrogen atom, an alkyl radical containing up to 6 carbon atoms, an acyl radical, a phenylalkyl or phenylalkenyl radical, the phenyl moiety of which can be substituted by halogen, alkyl or trifluoromethyl, C is a --(CH2)m -- radical, in which m is 0, 1, 2 or 3, or a branched C2 -C5 alkylene radical, whereby a methylene radical --CH2 -- of the group C can be replaced by an oxygen or sulphur atom or by a hydroxymethylene radical --CHOH-- or carbonyl group --CO--, B is a 1,2-, 1,3-, 1,4-cyclohexylidene or 1,2- or 1,3-cyclopentylidene radical.
