74918-57-3Relevant articles and documents
LIPIDS FOR LIPID NANOPARTICLE DELIVERY OF ACTIVE AGENTS
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Page/Page column 54, (2020/05/21)
Compounds are provided having the following structure: (I) or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein G1, R1, R2, L, and n are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.
LIPID DELIVERY OF THERAPEUTIC AGENTS TO ADIPOSE TISSUE
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Page/Page column 147-148, (2018/11/10)
A method of treating a disease mediated by protein expression in adipose tissue by intraperitoneally administering a composition comprising a lipid nanoparticle encapsulating or associated with a therapeutic agent (e.g., a nucleic acid), thereby delivering the therapeutic agent to adipose tissue of the subject and altering protein expression in the adipose tissue is provided herein. A method for delivering a therapeutic agent to adipose tissue of a subject in need thereof is also provided.
Method for cleaving alpha carbon-carbon single bonds in ketone under condition of metal-free catalysis
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Paragraph 0017; 0020, (2017/10/07)
The invention discloses a method for selectively activating and cleaving alpha carbon-carbon single bonds in ketone under the condition of metal-free catalysis. The method is characterized in that the alpha carbon-carbon single bonds in the ketone are activated and cleaved by solvent induction and driving of intermediate structure factors formed by the ketone and hydrazine without metal catalysts. Transition metal for catalysis is omitted, the method is environmentally friendly, reaction cost is reduced to a certain degree, methodology of selective cleavage of the carbon-carbon single bonds is enriched, and a new idea is provided for activation of inertial chemical bonds under mild conditions.