74919-32-7Relevant academic research and scientific papers
The amination of 3-bromo-2-ethoxy-1,5-naphthyridine. A reinvestigation.
Haak, H. J. W. van den,Plas, H. C. van der
, p. 83 - 86 (2007/10/02)
The reaction of 3-bromo-2-ethoxy-1,5-naphthyridine with KNH2/NH3 was reinvestigated.The procedure, described in the literature for the preparation of the title compound does not lead to this compound but to the isomeric 3-bromo-1-ethyl-1,5-naphthyridin-2(1H)-one.Reaction of this compound with KNH2/NH3 yields 3- and 4-amino-1-ethyl-1,5-naphthyridin-2(1H)-one, the latter being the main product.The title compound was prepared on reacting 2,3-dibromo-1,5-naphthyridine with sodium ethoxide.A mixture of 3- and 4-amino-2-ethoxy-1,5-naphthyridine was obtained on amination of 3-bromo-2-ethoxy-1,5-naphthyridine.In both cases the intermediacy of the respective 3,4-didehydro compounds was proposed.
