749216-36-2Relevant academic research and scientific papers
Process for the preparation of pyridinyl and pyrimidinyl mono-fluorinated beta keto-esters
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Page 4, (2008/06/13)
The present invention relates to a process for preparing pyridinyl and pyrimidinyl mono-fluorinated beta keto esters of formula (I): ???wherein:R1 represents a pyridine ring or a pyrimidine ring, the rings being optionally substituted by a C3-6 cycloalkyl group, a C1-4 alkyl group, a C1-4 alkoxy group, a benzyl group or a halogen atom;R2 represents a hydrogen atom, a C1-6 alkyl group or a halogen atom; andR3 represents a C1-6 alkyl group; by reacting with fluorine a compound of formula (II) ???wherein R1, R2 and R3 have the same meaning as defined above. Pyridinyl and pyrimidinyl mono-fluorinated beta keto esters of formula (I).
