74924-36-0Relevant academic research and scientific papers
Synthesis and pharmacological evaluation of 6,7-indolo/thiazolo-morphinans - Further SAR of levorphanol
Zhang, Ao,Li, Fuying,Ding, Chunyong,Yao, Qizhen,Knapp, Brian I.,Bidlack, Jean M.,Neumeyer, John L.
, p. 2747 - 2751 (2007)
To further extend the structure-activity relationships of levorphanol, two series of novel morphinans were prepared by incorporation of an indole or aminothiazole fragment to the hexyl ring (ring C) in levorphanol. Such morphinans differed from previously reported ligands in that such indole- or aminothiazole-containing morphinans displayed enhanced binding affinity to the δ opioid receptor, while the affinity to κ and μ receptors was slightly reduced.
