74925-06-7Relevant academic research and scientific papers
A kind of the geminally alkyl boric acid ester compound and its preparation method and application (by machine translation)
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Paragraph 0449-0457, (2019/02/13)
The invention discloses a geminally alkyl boric acid ester compound and its preparation method and application. The structure of the compound of formula (I) as shown; wherein R is or ; R1 Is phenyl, substituted phenyl, biphenyl or thiophene; R2 Hydrogen, halogen, hydroxy, C1 - 4 Alkyl, C1 - 4 Alkoxy, phenyl, substituted phenyl; R3 Is phenyl or substituted phenyl. The compound of the invention the structure is stable, at the same time with two alkyl and boric acid ester, can be used as a raw material, more simple, convenient, and rapid preparation in a pharmaceutically has high-value of the compound. In addition, the preparation of the compounds is simple, the preparation method of the reaction substrate has wide applicability, can be prepared a plurality of the geminally alkyl boric acid ester compound; at the same time, the method of the mild reaction conditions, without metal reagent, does not need high temperature or high pressure, does not need to be acid or alkali additive, and the reaction time is short, simple and convenient operation, after treatment is simple, is a high-efficient synthetic geminally halothane base boron ester compounds. (by machine translation)
gem-Difluorination of Alkenyl N-methyliminodiacetyl Boronates: Synthesis of α- and β-Difluorinated Alkylborons
Lv, Wen-Xin,Li, Qingjiang,Li, Ji-Lin,Li, Zhan,Lin,Tan, Dong-Hang,Cai, Yuan-Hong,Fan, Wen-Xin,Wang, Honggen
supporting information, p. 16544 - 16548 (2018/11/23)
Organofluorine compounds are widely used in pharmaceutical, agrochemical, and materials sciences. The syntheses and applications of fluorinated organoborons facilitate the rapid and modular assemblies of fluorine-containing molecules because of the versatility of C?B bonds in diverse chemical transformations. Reported herein is a migratory geminal difluorination of aryl-substituted alkenyl N-methyliminodiacetyl (MIDA) boronates using commercially available Py?HF as the fluorine source and hyperiodine as the oxidant. The protocol offers facile access to α- and β-difluorinated alkylboron compounds, both of which have previously been challenging to prepare. Mild reaction conditions, broad substrate scope, good functional-group tolerance, and moderate to good yields were observed. The utility of these products is demonstrated by further transformations of the C?B bond into other valuable functional groups.
Geminal difluorination of α,α’- disubstituted styrenes using fluoro-benziodoxole reagent. Migration aptitude of the α-substituents
Ilchenko, Nadia O.,Szabó, Kálmán J.
, p. 104 - 109 (2017/09/06)
α,α’-Disubstituted styrenes undergo a difluorination-rearrangement reaction with fluoro-benzoiodoxole reagent 1. The reaction is catalyzed by Pd(MeCN)4(BF4)2 and Cu(MeCN)4PF6. We have studied the rear
