749257-70-3

Basic information

• Product Name: 1-(5-methylpyridin-2-yl)hydrazine
• Synonyms: 1-(5-methylpyridin-2-yl)hydrazine
• CAS NO: 749257-70-3
• Molecular Formula: C₉H₁₀N₆
• Molecular Weight: 123.15576
• Mol File: 749257-70-3.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(5-methylpyridin-2-yl)hydrazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(5-methylpyridin-2-yl)hydrazine(749257-70-3)
• EPA Substance Registry System: 1-(5-methylpyridin-2-yl)hydrazine(749257-70-3)

Safety Data

• Hazardous Substances Data: 749257-70-3(Hazardous Substances Data)

Usage

General Description

1-(5-methylpyridin-2-yl)hydrazine, also known as 5-methylisonicotinohydrazide, is a chemical compound with the molecular formula C7H10N4. It is a hydrazine derivative that consists of a pyridine ring substituted with a methyl group at the 5-position and attached to a hydrazine group at the 2-position. 1-(5-methylpyridin-2-yl)hydrazine is primarily used in pharmaceutical research, particularly in the development of potential antituberculosis drugs. It has shown potential as an inhibitor of enzyme InhA, which is involved in the synthesis of mycolic acids in Mycobacterium tuberculosis, the bacterium that causes tuberculosis. Additionally, this compound has been investigated for its potential antimicrobial and anticancer activities. Its versatile chemical structure and potential biological activities make 1-(5-methylpyridin-2-yl)hydrazine an interesting compound for further research and development in the field of medicinal chemistry.

Upstream product

• 749257-69-0 5-(3-methylpyridine-2-yl)-3-methylsulfanyl[1,2,4]triazine 

Downstream Products

• 749259-37-8 [7-(3-methylpyridin-2-yl)[1,2,4]triazolo[4,3-b][1,2,4]triazin-3-yl]-(4-trifluoromethylphenyl) amine 

Relevant articles and documents

SUBSTITUTED AMINO HETEROCYCLES AS VR-1 ANTAGONISTS FOR TREATING PAIN

The present invention provides compounds of formula I: in which: one of T1and T4 is N and the other is C; T2 and T3 are independently N or C(CH2)nR2; X, Y and Z are independently N or C(CH2)nR3; R1 is Ar1 or R1 is C1-6alkyl optionally substituted with one or two groups Ar1; Ar1 is an optionally substituted cyclohexyl, piperidinyl, piperazinyl, morpholinyl, adamantyl, phenyl, naphthyl, a six-membered heteroaromatic ring containing one, two or three nitrogen atoms, a five-membered heteroaromatic ring containing one, two, three or four heteroatoms chosen from O, N and S, at most one O or S atom being present, or a nine- or ten-membered bicyclic heteroaromatic ring in which phenyl or a six-membered heteroaromatic ring as defined above is fused to a six-or five-membered heteroaromatic ring as defined above; Ar is an optionally substituted phenyl, a six-membered heteroaromatic ring containing one, two or three nitrogen atoms or a five-membered heteroaromatic ring containing one, two, three or four heteroatoms chosen from O, N and S, at most one heteroatom being O or S, Ar being optionally substituted by one, two or three groups chosen from halogen, CF3, OCF3, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, nitro, cyano, isonitrile, hydroxy, C1-6alkoxy, C1-6alkylthio, -NR6R7, -CONR6R7, -COH, CO2H, C1-6alkoxycarbonyl, haloC1-6alkyl, hydroxyC1-6alkyl, aminoC1-6alkyl, C1-6alkylcarbonyl and a five-membered heteroaromatic ring containing one, two, three or four heteroatoms chosen from O, N and S, at most one heteroatom being O or S, optionally substituted by C1-6alkyl, halogen, amino, hydroxy or cyano; or a pharmaceutically acceptable salt thereof as a VR-1 ligand; pharmaceutical compositions comprising it; its use in therapy; use of it in the manufacture of a medicament to treat pain; and methods of treating subjects suffering from pain.