749260-72-8

Upstream product

• 566927-61-5 (7R,9S,10S)-1-Benzyloxy-9-methoxy-10-methoxymethoxy-2,2-dimethyl-7-triethylsilanyloxy-dodec-11-ene-3,5-dione 
• 566927-83-1 (7S,9S,10S)-1-Benzyloxy-5-hydroxy-9-methoxy-10-methoxymethoxy-2,2-dimethyl-7-triethylsilanyloxy-dodec-11-en-3-one 
• 566927-57-9 (3S,4S,6S)-8-(4-Methoxy-benzyloxy)-3-methoxymethoxy-6-triethylsilanyloxy-oct-1-en-4-ol 
• 566927-58-0 Triethyl-{(1S,3S,4S)-3-methoxy-1-[2-(4-methoxy-benzyloxy)-ethyl]-4-methoxymethoxy-hex-5-enyloxy}-silane 
• 566927-63-7 (2S,4S)-6-(2-Benzyloxy-1,1-dimethyl-ethyl)-2-((2S,3S)-2-methoxy-3-methoxymethoxy-pent-4-enyl)-3,4-dihydro-2H-pyran-4-ol 
• 566927-62-6 (R)-6-(2-Benzyloxy-1,1-dimethyl-ethyl)-2-((2S,3S)-2-methoxy-3-methoxymethoxy-pent-4-enyl)-2,3-dihydro-pyran-4-one 
• 566927-55-7 Triethyl-{(R)-1-[2-(4-methoxy-benzyloxy)-ethyl]-but-3-enyloxy}-silane 
• 749260-70-6 (3S,5S,6S)-5-Methoxy-6-methoxymethoxy-3-triethylsilanyloxy-oct-7-en-1-ol 
• 566927-56-8 (S)-5-(4-Methoxy-benzyloxy)-3-triethylsilanyloxy-pentanal 
• 566927-60-4 (3R,5S,6S)-5-Methoxy-6-methoxymethoxy-3-triethylsilanyloxy-oct-7-enal 
• 325172-29-0 (3R)-1-[(4-methoxybenzyl)oxy]hex-5-en-3-ol 
• 61674-96-2 4-(benzyloxy)-3,3-dimethylbutan-2-one 
• 566927-64-8 (2S,3S,4S,6S)-2-(2-Benzyloxy-1,1-dimethyl-ethyl)-2-methoxy-6-((2S,3S)-2-methoxy-3-methoxymethoxy-pent-4-enyl)-tetrahydro-pyran-3,4-diol 
• 74-88-4 methyl iodide 

Downstream Products

• 566927-66-0 (2R,3S)-4-[(2R,4S,5S,6S)-6-(2-Benzyloxy-1,1-dimethyl-ethyl)-4,6-dimethoxy-5-triethylsilanyloxy-tetrahydro-pyran-2-yl]-3-methoxy-2-methoxymethoxy-butyric acid methyl ester 
• 566927-65-9 [(2S,3S,4S,6R)-2-(2-Benzyloxy-1,1-dimethyl-ethyl)-2,4-dimethoxy-6-((2S,3S)-2-methoxy-3-methoxymethoxy-pent-4-enyl)-tetrahydro-pyran-3-yloxy]-triethyl-silane 

Relevant academic research and scientific papers

SYNTHESIS OF PELORUSIDE A AND ANALOGS THEREOF FOR USE AS ANTITUMOR AGENTS

The present invention provides (+)- Peloruside A and analogs thereof having microtubule-stabilizing activity, and a process for synthesizing these compounds. Also provided are intermediates and a process for synthesizing thereof. These compounds exhibit antiproliferative activity and are useful for treating cancer.

Total synthesis and absolute configuration of the novel microtubule-stabilizing agent peloruside A

A unique configuration-dependent mechanistic switch, observed when epimeric seco-acids are subjected to typical Mitsunobu lactonization conditions, is just one of the many unexpected, yet insightful surprises of a synthetic adventure culminating in the fi