74938-88-8

Basic information

• Product Name: 4-Amidinophenylmethanesulfonyl fluoride hydrochloride
• Synonyms: P-APMSF;P-APMSF, HYDROCHLORIDE;(P-AMIDINOPHENYL)METHANESULFONYL FLUORIDE HYDROCHLORIDE;P-AMIDINOPHENYLMETHYLSULFONYLFLUORIDE, HCL;P-AMIDINOPHENYLMETHYL-SULFONYLFLUORIDE HYDROCHLORIDE;4-APMSF;4-AMIDINOBENZYLSULFONYL FLUORIDE HYDROCHLORIDE;(4-AMIDINOPHENYL)METHANESULFONYL FLUORIDE
• CAS NO: 74938-88-8
• Molecular Formula: C8H10ClFN2O2S
• Molecular Weight: 252.69
• Product Categories: inhibitor
• Mol File: 74938-88-8.mol
• Article Data: 1

Chemical Properties

• Melting Point: ~205 °C (dec.)
• Boiling Point: 405.2 °C at 760 mmHg
• Flash Point: 198.8 °C
• Appearance: /
• Vapor Pressure: 5.85E-07mmHg at 25°C
• Storage Temp.: −20°C
• Solubility: H2O: 50 mM Stable when aliquoted at −20°C. Hal
• BRN: 9083148
• CAS DataBase Reference: 4-Amidinophenylmethanesulfonyl fluoride hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Amidinophenylmethanesulfonyl fluoride hydrochloride(74938-88-8)
• EPA Substance Registry System: 4-Amidinophenylmethanesulfonyl fluoride hydrochloride(74938-88-8)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38
• Safety Statements: 22-24/25-36-26
• WGK Germany: 3
• F: 10-21
• Hazardous Substances Data: 74938-88-8(Hazardous Substances Data)

Usage

Description

p-APMSF is an irreversible inhibitor of serine proteases with Ki values of 1.02, 1.18, 1.5, and 1.54 μM for bovine trypsin, human thrombin, bovine plasmin, and bovine Factor Xa, respectively. It is selective for these proteases over bovine chymotrypsin and acetylcholinesterase.

Biochem/physiol Actions

Irreversible inhibitor of serine proteases with lysine or arginine substrate specificities. Effective concentration 10-100 μM. Frequently used to characterize newly discovered proteases.

InChI:InChI=1/C8H9FN2O2S.ClH/c9-14(12,13)5-6-1-3-7(4-2-6)8(10)11;/h1-4H,5H2,(H3,10,11);1H

Downstream Products

• 1456610-68-6 C₂₇H₄₀N₁₀O₄S 

Relevant articles and documents

Amidinophenylmethylsulfonylfluoride

A new compound amidinophenylmethylsulfonylfluoride is formed and preferably used in the para isomer form as an irreversible inactivator of selected serine proteases.