74944-95-9

Upstream product

• 121-71-1 3-Hydroxyacetophenone 
• 108-24-7 acetic anhydride 
• 76485-18-2 trans-3,3'-Dimethoxy-α,β-dimethylstilben 
• 586-37-8 1-(3-Methoxyphenyl)ethanone 
• 76473-12-6 1,1-Dioxo-2,5-dimethyl-2,5-di-(3'-methoxyphenyl)-Δ³-1,3,4-thiadiazolin 
• 76473-10-4 [1-(3-methoxyphenyl)ethylidene]hydrazine 

Downstream Products

• 1229392-15-7 (Z)-3,3'-(1,2-dimethyl-1,2-ethenediyl)bis[2-[(dimethylamino)methyl]phenol] 
• 1229392-16-8 (E)-3,3'-(1,2-dimethyl-1,2-ethenediyl)bis[2-[(dimethylamino)methyl]phenol] 
• 80149-89-9 Acetic acid 3-[3-(3-acetoxy-phenyl)-2,3-dimethyl-oxiranyl]-phenyl ester 
• 1229392-10-2 C₂₆H₃₈N₂O₂ 
• 1229392-13-5 C₂₆H₃₈N₂O₂ 

Relevant academic research and scientific papers

Compositions and methods for adipocyte modulation

Modified stilbenoids and formulations thereof are provided. The modified stilbenoids can include one or more amino or amino-alkyl substituents. The formulation can be for the treatment or prevention of obesity and the modified stilbenoid present in an eff

Identification of novel SAR properties of the Jak2 small molecule inhibitor G6: Significance of the para-hydroxyl orientation

In this study, we analyzed the structure-activity relationship properties of the small molecule Jak2 inhibitor G6. We synthesized a set of derivatives containing the native para-hydroxyl structure or an alternative meta-hydroxyl structure and examined their Jak2 inhibitory properties. We found that the para-hydroxyl derivative known as NB15 had excellent Jak2 inhibitory properties in silico, in vitro, and ex vivo when compared with meta-hydroxyl derivatives. These results indicate that NB15 is a potent derivative of the Jak2 inhibitor G6, and that maintaining the para-hydroxyl orientation of G6 is critical for its Jak2 inhibitory potential.