74965-56-3

Upstream product

• 1053180-73-6 methyl (6R)-2-oxo-6-(prop-2-en-1-yl)cyclohexane-1-carboxylate 
• 74965-54-1 (R)-2-Oxo-bicyclo[4.1.0]heptane-1-carboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester 
• 74965-53-0 3-Oxo-oct-7-enoic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester 
• 74965-55-2 (R)-2-Allyl-6-oxo-cyclohexanecarboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester 

Relevant academic research and scientific papers

Catalytic enantioselective Hosomi-Sakurai conjugate allylation of cyclic unsaturated ketoesters

(Chemical Equation Presented) No fancy catalyst required: The copper-catalyzed enantioselective conjugate allylation of activated cyclic enones affords products in up to >98% ee. Reactions proceed to high conversion in the presence of commercially availab

Preparation of Cyclohexanones and Cyclopentanones of High Optical Purity

Cyclization of 3, prepared from 1-menthol, led to a 1:1 mixture of 4 and 5.These diastereomeric ketones, readily separated by chromatography, are versatile intermediates for the preparation of alkylated cyclohexanones.The absolute configuration of 5 was assigned by conversion to the known hydroxy ketal 9.This approach works equally well for the cyclopentane series.Thus, alkylated cyclohexanones and cyclopentanones of known absolute configuration will for the first time be routinely available.