7497-07-6

Basic information

• Product Name: 3,4-Dichloro-N-(1-Methylbutyl)benza-Mide
• Synonyms: 3,4-Dichloro-N-(1-Methylbutyl)benza-Mide;NSC 405020;3,4-Dichloro-N-(1-methylbutyl)-benzamide NSC405020;NSC 405020 3,4-Dichloro-N-(1-methylbutyl)-benzamide;NSC 405020, >=98%;NSC 405020, 7497-07-6;NSC405020, 98%, MT1-MMP inhibitor
• CAS NO: 7497-07-6
• Molecular Formula: C12H15Cl2NO
• Molecular Weight: 260.1596
• EINECS: -0
• Product Categories: Inhibitors
• Mol File: 7497-07-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 353.7°C at 760 mmHg
• Flash Point: 167.7°C
• Appearance: /
• Density: 1.182g/cm³
• Vapor Pressure: 3.52E-05mmHg at 25°C
• Refractive Index: 1.531
• Storage Temp.: room temp
• Solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
• PKA: 13.38±0.46(Predicted)
• Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
• CAS DataBase Reference: 3,4-Dichloro-N-(1-Methylbutyl)benza-Mide(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-Dichloro-N-(1-Methylbutyl)benza-Mide(7497-07-6)
• EPA Substance Registry System: 3,4-Dichloro-N-(1-Methylbutyl)benza-Mide(7497-07-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26-24/25
• RIDADR: 3077
• WGK Germany: 3
• Hazardous Substances Data: 7497-07-6(Hazardous Substances Data)

Usage

Description

NSC-405020 (7497-07-6) is a membrane type-1 matrix metalloproteinase (MMP14 or MT1-MMP) inhibitor that prevents homodimerization and inhibits MMP14’s protumorigenic activity?in vivo. (IC50?> 100 μM). Inhibition is via interaction with the hemopexin domain (PEX) of MMP14. NSC-405020 does not interfere with the catalytic activity of MT1-MMP or MMP-2.? Suppresses bone erosion in a c-Fos-deficient mouse model.2?Decreases arsenic-mediated invasion of human squamous cell carcinoma HSC5 cells.3

Uses

NSC 405020 is a novel, selective, and noncatalytic membrane type-1 matrix metalloproteinase (MT1-MMP) inhibitor that directly interacts with the homopexin (PEX) domain of MT1-MMP.

References

1) Remacle?et al.?(2012),?Novel MT1-MMP small-molecule inhibitors based on insights into hemopexin domain function in tumor growth;? Cancer Res.,?72?2339 2) Kittaka?et al.?(2018)?Cherubism Mice Also Deficient in c-Fos Exhibit Inflammatory Bone Destruction Executed by Macrophages That Express MMP14 Despite the Absence of TRAP+ Osteoclasts?; J. Bone Miner. Res.,?33?167 3) Thang?et al.?(2014)?Bidirectional functions of arsenic as a carcinogen and an anti-cancer agent in human squamous cell carcinoma; PLoS One,?9(5)?e96945

InChI:InChI=1/C12H15Cl2NO/c1-3-4-8(2)15-12(16)9-5-6-10(13)11(14)7-9/h5-8H,3-4H2,1-2H3,(H,15,16)

Relevant articles and documents

Phytotoxicity and selectivity of homologous series of N-alkyl and N-dialkyl-3,4-dichlorbenzamides

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