7497-54-3

Usage

Uses

Used in Pharmaceutical Industry:
2-bromoacridin-9(10H)-one is used as a building block for the synthesis of various pharmaceuticals due to its potential biological activities, such as antimicrobial, antiviral, and antitumor properties. Its ability to interact with DNA and inhibit topoisomerase enzymes makes it a promising candidate for the development of new drugs.
Used in Agrochemical Industry:
2-bromoacridin-9(10H)-one is used as a building block for the synthesis of various agrochemicals, leveraging its antimicrobial properties to create compounds that can be used in agriculture to protect crops from diseases and pests.
Used in Organic Chemistry Research:
2-bromoacridin-9(10H)-one is used as a significant compound in the field of organic chemistry for research purposes. Its diverse range of potential applications and biological activities make it an important subject for further exploration and development of new chemical compounds and drug candidates.

Upstream product

• 201230-82-2 carbon monoxide 
• 54446-36-5 4-bromodiphenylamine 

Downstream Products

• 7497-57-6 4-(2-bromo-acridin-9-yl)-N,N-dimethyl-aniline 
• 63484-66-2 2-bromo-10-(2-phenyl-thiazol-4-ylmethyl)-10H-acridin-9-one 
• 63484-65-1 2-bromo-10-(5-bromo-2-phenyl-thiazol-4-ylmethyl)-10H-acridin-9-one 
• 578-95-0 10H-acridin-9-one 

Relevant academic research and scientific papers

Palladium/copper Co-catalyzed oxidative C-H/C-H carbonylation of diphenylamines: A way to access acridones

An efficient palladium/copper co-catalyzed oxidative double C(sp2)-H functionalization/carbonylation of diphenylamines for synthesis of acridones has been developed. This method utilizes readily available starting materials and mild reaction conditions. The protocol provides a simple, efficient, and atomeconomic way to access acridones. Notably, the present protocol has excellent functional group tolerance and application value.

Method for synthesizing acridone derivatives by means of palladium-copper co-catalysis

The invention discloses a method for synthesizing acridone derivatives by means of palladium-copper co-catalysis. The method comprises the steps that on the condition that palladium chloride, copper pivalate and di-tert-butyl peroxide or oxygen co-exist, diphenylamine compounds including symmetric diphenylamine and asymmetric diphenylamine are dissolved in an anhydrous organic solvent, all the materials are mixed to be uniform, a reaction is conducted for 20 h to 30 h under the condition of 80 DEG C to 120 DEG C in a carbon monoxide atmosphere, separation and purification are conducted, and the acridone derivatives can be obtained. According to the method for synthesizing the acridone derivatives by means of palladium-copper co-catalysis, the preparation method is simple, the diphenylamine compounds which are simple and easy to obtain are used as the raw materials, and the acridone derivatives are directly constructed through C-H/C-H oxidative carbonylation; the preparation condition is mild, and the target product can be obtained in a high-selectivity mode at 80 DEG C to 120 DEG C; the acridone derivatives have good substrate applicability, the range of substrates is greatly expanded, and the acridone derivatives have a great application prospect in biological medicine and materials and the like.