74972-79-5Relevant academic research and scientific papers
Regioselective N9 alkylation of purine rings assisted by β-cyclodextrin
Zhang, Qian,Cheng, Gang,Huang, Yong-Zhen,Qu, Gui-Rong,Niu, Hong-Ying,Guo, Hai-Ming
experimental part, p. 7822 - 7826 (2012/09/22)
Under the assistance of β-cyclodextrin, purine was effectively alkylated at N9 together with up to 99% conversion and good to excellent yield using water as the solvent. High regioselectivity-N9/N7 selectivity>99:1 was attributed to the β-cyclodextrin cav
Mitsunobu reactions for the synthesis of carbocyclic analogues of nucleosides: Examintion of the regioselectivity
Toyota,Katagiri,Kaneko
, p. 1295 - 1305 (2007/10/02)
In order to provide a general synthetic method for carbocyclic nucleosides, regioselectivities in Mitsunobu reaction of purine, pyrimidin-2-one and their substituted derivatives with a variety of alcohols with a variety of alcohols were examined and found to depend upon both substituents of the bases and kind of the alcohols.
The alkylation of 6-chloropurine with alcohols by Mitsunobu reaction
Toyota,Katagiri,Kaneko
, p. 1039 - 1041 (2007/10/02)
A general procedure has been developed for the preparation of 9-alkylated adenines by the Mitsunobu reaction between 6-chloropurine and several alcohols, followed by the replacement of the chlorine with ammonia. A lesser amount of the 7-alkylpurines was also obtained, irrespective of the alcohol used.
