74973-52-7Relevant academic research and scientific papers
Bicyclic imidazole-4-one derivatives: A new class of antagonists for the orphan G protein-coupled receptors GPR18 and GPR55
Rempel,Atzler,Behrenswerth,Karcz,Schoeder,Hinz,Kaleta,Thimm,Kiec-Kononowicz,Müller
, p. 632 - 649 (2014/05/06)
GPR18 and GPR55 are orphan G protein-coupled receptors (GPCRs) that interact with certain cannabinoid (CB) receptor ligands. In the present study bicyclic imidazole-4-one derivatives were discovered as new scaffolds for the development of antagonists for
REACTION OF 5,5-DIPHENYL-2-THIOHYDANTOIN WITH 1,4-DIBROMOBUTANE. THE CRYSTAL AND MOLECULAR STRUCTURE OF 2,3,4,5-TETRAHYDRO-7,7-DIPHENYLIMIDAZO--THIAZEPINE-8(7H)-ONE
Kiec-Kononowicz, Katatzyna,Zatorski, Andzrej,Karolak-Wojciechowska, Janina
, p. 191 - 200 (2007/10/02)
The reaction of 5,5-diphenyl-2-thiohydantoin (1) (DPTH) or its potassium salt (DPTH-K) with 1,4-dibromobutane gave two isomeric bicyclic products;2,3,4,5-tetrahydro-7,7 diphenylimidazo-thiazepine-8(7H)one (6) and 2,3,4,5-tetrahydro-8,8-diphenylimid
REACTION OF 5,5-DIPHENYL-2-THIOHYDANTOIN WITH 1,3-DIBROMOPROPANE UNDER PHASE TRANSFER CATALYTIC CONDITIONS. CRYSTAL AND MOLECULAR STRUCTURE OF 2,3,4,5-TETRAHYDRO-7,7-DIPHENYLIMIDAZO--THIAZINE-6(7H)-ONE
Kiec-Kononowicz, K.,Zejc, A.,Mikolajczyk, M.,Zatorski, A.,Karolak-Wojciechowska, J.,Wieczorek, M. W.
, p. 409 - 415 (2007/10/02)
The reaction of the potassium salt of 5,5-diphenyl-2-thiohydantoin with 1,3-dibromopropane and triethylamine carried out under phase transfer catalytic conditions gave almost quantitatively two isomeric diphenylimidazothiazine 2 and 3 in a ratio ca 1:2. 2
REACTION OF 5,5-DIPHENYL-2-THIOHYDANTOIN WITH 1,3-DIBROMOPROPANE. CRYSTAL AND MOLECULAR STRUCTURE OF 2,3,4,5-TETRAHYDRO-6,6-DIPHENYLIMIDAZO-THIAZINE-7(6H)-ONE
Kiec-Kononowicz, K.,Zejc, A.,Mikolajczyk, M.,Zatorski, A.,Karolak-Wojciechowska, J.,Wieczorek, M. W.
, p. 1079 - 1088 (2007/10/02)
The reaction between the potassium salt of 5,5-diphenyl-2-thiohydantoin (1) and 1,3-dibromopropane carried out in DME under anhydrous conditions has been found to give two isomeric diphenylimidazothiazines 2 and 3.When the reaction of 1 with 1,3-dibromopropane was performed in protic solvents (EtOH, HOH, NaOH) 2 and 3-(3-mercaptopropyl)-5,5-diphenylthiohydantoin (4) were formed.The latter is the product of hydrolysis of 3 taking place under the reaction conditions. 2,3,4,5-Tetrahydro-6,6-diphenylimidazo-thiazine-7(6H)-one (2) crystallises in space group P21/n with a=10.812(3), b=14.905(7), c=9.885(4) Angstroem, β=104.91(2) deg.The 5-membered ring in 2 is planar whereas the 6-membered thiazine ring adopts the sofa conformation.
