74979-64-9Relevant academic research and scientific papers
COMPOUNDS AND COMBINATIONS THEREOF FOR INHIBITING BETA-AMYLOID PRODUCTION AND METHODS OF USE THEREOF
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Page/Page column 149-150, (2010/11/29)
Provided are compounds which can be used in combination for treating diseases associated with a condition associated with cerebral accumulation of Alzheimer’s amyloid, such as Alzheimer’s disease. Also provided are methods of treating or reducing the risk of developing β-amyloid production, β-amyloid deposition, β-amyloid neurotoxicity (including abnormal hyperphosphorylation of tau) and microgliosis associated with cerebral accumulation of Alzheimer’s amyloid by administering therapeutically effective amounts of compounds which in combination can decrease β-amyloid production and capacitative calcium entry in cells. Further provided are methods for diagnosing diseases associated with cerebral accumulation of Alzheimer’s amyloid in animals or humans by administering diagnostically effective amounts of the compounds.
1-ARYL- AND 1-BENZYL-3,5-DIETHOXYCARBONYL-1,4-DIHYDROPYRIDINES
Sausin, A.E.,Chekavichus, B.S.,Lusis, V.K.,Dubur, G.Ya.
, p. 377 - 385 (2007/10/02)
The possibility has been studied of using anilines in the Hantzsch synthesis.It has been shown that, with the exception of those containing strong electron-accepting substituents, they take part in this reaction with the formation of 1-aryl-1,4-dihydropyridines.The reaction largely depends on the nature of the substituents in the aniline and in the benzaldehyde and is promoted by electron-accepting substituents in the aldehyde and electron-donating substituents in the amine.The mechanism of the reaction is discussed.A number of 1-benzyl-1,4-dihydroxypyridines have been synthesized.The UV, IR, and PMR spectra and the electro-oxidation of the compounds obtained have been studied.
