749858-85-3Relevant academic research and scientific papers
Rapid oligosaccharide synthesis using a fluorous protective group
Miura, Tsuyoshi,Goto, Kohtaro,Waragai, Hideki,Matsumoto, Hiroharu,Hirose, Yuriko,Ohmae, Masashi,Ishida, Hide-Ki,Satoh, Ai,Inazu, Toshiyuki
, p. 5348 - 5353 (2004)
The Bfp-OH, a novel fluorous protecting reagent, was able to be easily prepared. The Bfp group was readily introduced to a carbohydrate, removed in high yield, and recyclable after cleavage. The use of the Bfp group made it possible to synthesize a pentasaccharide by minimal column chromatography purification. Each synthetic intermediate was able to be easily purified only by simple fluorous-organic solvent extraction and monitored by TLC, NMR, and MS.
